Spatial organization of the somatosensory cortex revealed by osmFISH

Global efforts to create a molecular census of the brain using single-cell transcriptomics are producing a large catalog of molecularly defined cell types. However, spatial information is lacking and new methods are needed to map a large number of cell type–specific markers simultaneously on large tissue areas. Here, we describe a cyclic single-molecule fluorescence in situ hybridization methodology and define the cellular organization of the somatosensory cortex.

Published in:
Nature Methods, 15, 11, 932-935
Nov 01 2018

 Record created 2019-05-01, last modified 2020-10-29

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