000265302 001__ 265302
000265302 005__ 20190417160812.0
000265302 0247_ $$2doi$$a10.1016/j.brs.2018.12.972
000265302 02470 $$a10.1016/j.brs.2018.12.972$$2DOI
000265302 037__ $$aARTICLE
000265302 245__ $$aHand perceptions induced by single pulse transcranial magnetic stimulation over the primary motor cortex
000265302 260__ $$c2018-12-23
000265302 269__ $$a2018-12-23
000265302 336__ $$aJournal Articles
000265302 520__ $$aBackground When single pulse transcranial magnetic stimulation (TMS) is applied over the primary motor cortex (M1) with sufficient intensity, it evokes muscular contractions (motor-evoked potentials, MEPs) and muscle twitches (TMS-evoked movements). Participants may also report various hand sensations related to TMS, but the perception elicited by TMS and its relationship to MEPs and evoked movements has not been systematically studied. Objective The main aim of this work is to evaluate participants' kinesthetic and somatosensory hand perceptions elicited by single-pulse TMS over M1-hand area at different intensities of stimulation and their relation with MEPs and TMS-evoked movements. Methods We compared the number of MEPs (measured by electromyography), TMS-evoked movements (measured by an accelerometer) and participants' hand perception (measured by verbal report) elicited by TMS at different intensity of stimulation. This way, we estimated the amplitude of MEPs and the acceleration of TMS-evoked movements sufficient to trigger TMS evoked hand perceptions. Results We found that TMS-evoked hand perceptions are induced at 105% of the individual resting motor threshold, a value significantly different from the threshold inducing MEPs (about 100%) and TMS-evoked movements (about 110%). Our data indicate that only MEPs with an amplitude higher than 0.62 mV and TMS-evoked movements with acceleration higher than 0.42 m/s2 were associated with hand perceptions at threshold. Conclusions Our data reveal the main features of TMS-evoked hand perception and show that in addition to MEPs and TMS-evoked movements, this is a separate discernible response associated to single-pulse TMS over M1.
000265302 6531_ $$aTranscranial magnetic stimulation (TMS)Primary motor cortexMotor evoked potentialsTMS-evoked movementsTMS-evoked hand perceptionsAbsolute threshold
000265302 700__ $$aFranza, Matteo
000265302 700__ $$aSorrentino, Giuliana
000265302 700__ $$aVissani, Matteo
000265302 700__ $$aSerino, Andrea
000265302 700__ $$aBlanke, Olaf
000265302 700__ $$aBassolino, Michela
000265302 773__ $$tBrain Stimulation
000265302 8560_ $$fherberto.dhanis@epfl.ch
000265302 909C0 $$zBlumer, Eliane$$xU11025$$pLNCO$$mmarco.solca@epfl.ch$$0252325
000265302 909CO $$ooai:infoscience.epfl.ch:265302$$particle$$pSV
000265302 960__ $$aherberto.dhanis@epfl.ch
000265302 961__ $$afantin.reichler@epfl.ch
000265302 973__ $$aEPFL$$sPUBLISHED$$rREVIEWED
000265302 980__ $$aARTICLE
000265302 981__ $$aoverwrite
000265302 999C0 $$pCNP$$mbruno.herbelin@epfl.ch$$0252517$$zBlumer, Eliane$$xU12599