000263906 001__ 263906
000263906 005__ 20190215175058.0
000263906 0247_ $$a10.1111/1462-2920.14562$$2doi
000263906 02470 $$a10.1111/1462-2920.14562$$2DOI
000263906 037__ $$aARTICLE
000263906 245__ $$aEcological implications of gene regulation by TfoX and TfoY among diverse Vibrio species
000263906 260__ $$c2019-02-14
000263906 269__ $$a2019-02-14
000263906 336__ $$aJournal Articles
000263906 520__ $$aBacteria of the genus Vibrio are common members of aquatic environments where they compete with other prokaryotes and defend themselves against grazing predators. A macromolecular protein complex called the type VI secretion system (T6SS) is used for both purposes. Previous research showed that the sole T6SS of the human pathogen V. cholerae is induced by extracellular (chitin) or intracellular (low c‐di‐GMP levels) cues and that these cues lead to distinctive signalling pathways for which the proteins TfoX and TfoY serve as master regulators. In this study, we tested whether the TfoX‐ and TfoY‐mediated regulation of T6SS, concomitantly with natural competence or motility, was conserved in non‐cholera Vibrio species, and if so, how these regulators affected the production of individual T6SSs in double‐armed vibrios. We show that, alongside representative competence genes, TfoX regulates at least one T6SS in all tested Vibrio species. TfoY, on the other hand, fostered motility in all vibrios but had a more versatile T6SS response in that it did not foster T6SS‐mediated killing in all tested vibrios. Collectively, our data provide evidence that the TfoX‐ and TfoY‐mediated signalling pathways are mostly conserved in diverse Vibrio species and important for signal‐specific T6SS induction.
000263906 536__ $$aFNS$$c31003A 162551
000263906 536__ $$aH2020$$c724630-CholeraIndex
000263906 536__ $$aUS foundations$$c55008726
000263906 542__ $$fCC BY
000263906 6531_ $$atype VI secretion, regulatory networks, Vibrio species, natural competence for transformation, motility, c-di-GMP
000263906 700__ $$aMetzger, Lisa C.
000263906 700__ $$aMatthey, Noémie
000263906 700__ $$aStoudmann, Candice
000263906 700__ $$aCollas, Esther J.
000263906 700__ $$aBlokesch, Melanie
000263906 773__ $$tEnvironmental Microbiology$$jonline ahead of print
000263906 8560_ $$fmelanie.blokesch@epfl.ch
000263906 909C0 $$zBlumer, Eliane$$xU12076$$pUPBLO$$mmelanie.blokesch@epfl.ch$$0252246
000263906 909CO $$ooai:infoscience.epfl.ch:263906$$particle$$pSV
000263906 960__ $$amelanie.blokesch@epfl.ch
000263906 961__ $$afantin.reichler@epfl.ch
000263906 973__ $$aEPFL$$sPUBLISHED$$rREVIEWED
000263906 980__ $$aARTICLE
000263906 981__ $$aoverwrite