000262294 001__ 262294
000262294 005__ 20190107101843.0
000262294 022__ $$a0999-193X
000262294 022__ $$a1297-9686
000262294 02470 $$2isi$$a000450519100004
000262294 0247_ $$2doi$$a10.1186/s12711-018-0422-x
000262294 037__ $$aARTICLE
000262294 245__ $$aGenome-wide SNP profiling of worldwide goat populations reveals strong partitioning of diversity and highlights post-domestication migration routes
000262294 260__ $$aLondon$$bBMC$$c2018
000262294 269__ $$a2018-11-19
000262294 336__ $$aJournal Articles
000262294 520__ $$aBackground: Goat populations that are characterized within the AdaptMap project cover a large part of the worldwide distribution of this species and provide the opportunity to assess their diversity at a global scale. We analysed genome-wide 50K single nucleotide polymorphism (SNP) data from 144 populations to describe the global patterns of molecular variation, compare them to those observed in other livestock species, and identify the drivers that led to the current distribution of goats.
000262294 520__ $$aResults: A high degree of genetic variability exists among the goat populations studied. Our results highlight a strong partitioning of molecular diversity between and within continents. Three major gene pools correspond to goats from Europe, Africa and West Asia. Dissection of sub-structures disclosed regional gene pools, which reflect the main post-domestication migration routes. We also identified several exchanges, mainly in African populations, and which often involve admixed and cosmopolitan breeds. Extensive gene flow has taken place within specific areas (e.g., south Europe, Morocco and Mali-Burkina Faso-Nigeria), whereas elsewhere isolation due to geographical barriers (e.g., seas or mountains) or human management has decreased local gene flows.
000262294 520__ $$aConclusions: After domestication in the Fertile Crescent in the early Neolithic era (ca. 12,000 YBP), domestic goats that already carried differentiated gene pools spread to Europe, Africa and Asia. The spread of these populations determined the major genomic background of the continental populations, which currently have a more marked subdivision than that observed in other ruminant livestock species. Subsequently, further diversification occurred at the regional level due to geographical and reproductive isolation, which was accompanied by additional migrations and/or importations, the traces of which are still detectable today. The effects of breed formation were clearly detected, particularly in Central and North Europe. Overall, our results highlight a remarkable diversity that occurs at the global scale and is locally partitioned and often affected by introgression from cosmopolitan breeds. These findings support the importance of long-term preservation of goat diversity, and provide a useful framework for investigating adaptive introgression, directing genetic improvement and choosing breeding targets.
000262294 650__ $$aAgriculture, Dairy & Animal Science
000262294 650__ $$aGenetics & Heredity
000262294 650__ $$aAgriculture
000262294 650__ $$aGenetics & Heredity
000262294 6531_ $$agenetic diversity
000262294 6531_ $$alinkage disequilibrium
000262294 6531_ $$af-statistics
000262294 6531_ $$aorigins
000262294 6531_ $$aassociation
000262294 6531_ $$aresources
000262294 6531_ $$aancestry
000262294 6531_ $$aafrican
000262294 6531_ $$aeurope
000262294 6531_ $$abreeds
000262294 700__ $$aColli, Licia
000262294 700__ $$aMilanesi, Marco
000262294 700__ $$aTalenti, Andrea
000262294 700__ $$aBertolini, Francesca
000262294 700__ $$aChen, Minhui
000262294 700__ $$aCrisa, Alessandra
000262294 700__ $$aDaly, Kevin Gerard
000262294 700__ $$aDel Corvo, Marcello
000262294 700__ $$aGuldbrandtsen, Bernt
000262294 700__ $$aLenstra, Johannes A.
000262294 700__ $$aRosen, Benjamin D.
000262294 700__ $$0251641$$aVajana, Elia
000262294 700__ $$aCatillo, Gennaro
000262294 700__ $$0240604$$aJoost, Stephane
000262294 700__ $$aNicolazzi, Ezequiel Luis
000262294 700__ $$0248766$$aRochat, Estelle
000262294 700__ $$aRothschild, Max F.
000262294 700__ $$aServin, Bertrand
000262294 700__ $$aSonstegard, Tad S.
000262294 700__ $$aSteri, Roberto
000262294 700__ $$aVan Tassell, Curtis P.
000262294 700__ $$aAjmone-Marsan, Paolo
000262294 700__ $$aCrepaldi, Paola
000262294 700__ $$aStella, Alessandra
000262294 773__ $$j50$$q58$$tGenetics Selection Evolution
000262294 8560_ $$ffrancois.golay@epfl.ch
000262294 909CO $$ooai:infoscience.epfl.ch:262294$$particle$$pENAC
000262294 909C0 $$0252208$$mjerome.chenal@epfl.ch$$pCEAT$$xU10250$$yApproved$$zBlanc, Chantal
000262294 909C0 $$0252045$$mfrancois.golay@epfl.ch$$pLASIG$$xU10244$$yApproved$$zCharbonnier, Valérie
000262294 961__ $$amanon.velasco@epfl.ch
000262294 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000262294 980__ $$aARTICLE
000262294 980__ $$aWoS
000262294 981__ $$aoverwrite