Chemical Ligand Space of Cereblon

The protein cereblon serves as a substrate receptor of a ubiquitin ligase complex that can be tuned toward different target proteins by cereblon-binding agents. This approach to targeted protein degradation is exploited in different clinical settings and has sparked the development of a growing number of thalidomide derivatives. Here, we probe the chemical space of cereblon binding beyond such derivatives and work out a simple set of chemical requirements, delineating the metaclass of cereblon effectors. We report co-crystal structures for a diverse set of compounds, including commonly used pharmaceuticals, but also find that already minimalistic cereblon-binding moieties might exert teratogenic effects in zebrafish. Our results may guide the design of a post-thalidomide generation of therapeutic cereblon effectors and provide a framework for the circumvention of unintended cereblon binding by negative design for future pharmaceuticals.


Published in:
Acs Omega, 3, 9, 11163-11171
Year:
Sep 01 2018
Publisher:
Washington, AMER CHEMICAL SOC
ISSN:
2470-1343
Keywords:
Laboratories:




 Record created 2018-12-13, last modified 2019-04-18


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