Insertion of germanium atoms in high- nuclearity rhodium carbonyl compounds: synthesis, characterization and preliminary biological activity of the heterometallic [ Rh13Ge( CO) 25] 3-, [ Rh14Ge2( CO) 30] 2-and [ Rh12Ge( CO) 27] 4-clusters+

The reaction of the [Rh-7(CO)(16)](3-) cluster anion with Ge2+ salts, in different stoichiometric ratios and under different atmospheres, leads to the formation of new heterometallic Rh-Ge clusters, representing the first known examples of Rh carbonyl compounds containing interstitial germanium atoms. More specifically, under N-2 the reaction progressively affords the new [Rh13Ge(CO)(25)](3-) and [Rh14Ge2(CO)(30)](2-) clusters in good yields, with the Ge atoms located in cubic and square-anti-prismatic cavities, respectively. However, under a CO atmosphere, the [Rh13Ge(CO)(25)](3-) derivative undergoes a significant structural and chemical rearrangement giving the new compound, [Rh12Ge(CO)(27)](4-), where Ge is hosted in an icosahedral metal cage. All species have been characterized by IR spectroscopy and ESI mass spectrometry, and their structures have been elucidated by single-crystal X-ray diffraction. Additionally, preliminary biological tests on the [Rh13Ge(CO)(25)](3-) and [Rh14Ge2(CO)(30)](2-) clusters show that they are cytotoxic to various cell lines.


Published in:
Dalton Transactions, 47, 44, 15737-15744
Year:
Nov 28 2018
Publisher:
Cambridge, ROYAL SOC CHEMISTRY
ISSN:
1477-9226
1477-9234
Keywords:
Laboratories:




 Record created 2018-12-13, last modified 2019-06-19


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