000256926 001__ 256926
000256926 005__ 20190317001029.0
000256926 0247_ $$2doi$$a10.1038/s41557-018-0134-4
000256926 02470 $$a10.1038/s41557-018-0134-4$$2DOI
000256926 037__ $$aARTICLE
000256926 245__ $$aCarbohydrate stabilization extends the kinetic limits of chemical polysaccharide depolymerization
000256926 260__ $$c2018
000256926 269__ $$a2018
000256926 336__ $$aJournal Articles
000256926 520__ $$aPolysaccharide depolymerization is an essential step for valorizing lignocellulosic biomass. In inexpensive systems such as pure water or dilute acid mixtures, carbohydrate monomer degradation rates exceed hemicellulose—and especially cellulose—depolymerization rates at most easily accessible temperatures, limiting sugar yields. Here, we use a reversible stabilization of xylose and glucose by acetal formation with formaldehyde to alter this kinetic paradigm, preventing sugar dehydration to furans and their subsequent degradation. During a harsh organosolv pretreatment in the presence of formaldehyde, over 90% of xylan in beech wood was recovered as diformylxylose (compared to 16% xylose recovery without formaldehyde). The subsequent depolymerization of cellulose led to carbohydrate yields over 70% and a final concentration of ~5 wt%, whereas the same conditions without formaldehyde gave a yield of 28%. This stabilization strategy pushes back the longstanding kinetic limits of polysaccharide depolymerization and enables the recovery of biomass-derived carbohydrates in high yields and concentrations.
000256926 700__ $$aQuestell-Santiago, Ydna M.
000256926 700__ $$aZambrano-Varela, Raquel
000256926 700__ $$aTalebi Amiri, Masoud
000256926 700__ $$aLuterbacher, Jeremy S.
000256926 773__ $$tNature Chemistry$$j10$$k12$$q1222-1228
000256926 8564_ $$uhttps://infoscience.epfl.ch/record/256926/files/Graphical%20Abstract.png$$zTHUMBNAIL$$s99153
000256926 8564_ $$uhttps://infoscience.epfl.ch/record/256926/files/Main%20Text.pdf$$zFinal$$s1279006
000256926 8560_ $$fjherhau.yeap@epfl.ch
000256926 8564_ $$uhttps://infoscience.epfl.ch/record/256926/files/Graphical%20abstract.png$$s297119
000256926 909C0 $$xU12907$$pLPDC$$mjherhau.yeap@epfl.ch$$zBorel, Alain$$0252511
000256926 909CO $$qGLOBAL_SET$$pSB$$particle$$ooai:infoscience.epfl.ch:256926
000256926 960__ $$ajherhau.yeap@epfl.ch
000256926 961__ $$apierre.devaud@epfl.ch
000256926 973__ $$aEPFL$$sPUBLISHED$$rREVIEWED
000256926 980__ $$aARTICLE
000256926 981__ $$aoverwrite