000256348 001__ 256348
000256348 005__ 20190909115629.0
000256348 0247_ $$2doi$$a10.1109/TCBB.2018.2854776
000256348 037__ $$aARTICLE
000256348 245__ $$aMedCo: Enabling Secure and Privacy-Preserving Exploration of Distributed Clinical and Genomic Data
000256348 260__ $$c2019
000256348 269__ $$a2019
000256348 336__ $$aJournal Articles
000256348 520__ $$aThe increasing number of health-data breaches is creating a complicated environment for medical-data sharing and, consequently, for medical progress. Therefore, the development of new solutions that can reassure clinical sites by enabling privacy-preserving sharing of sensitive medical data in compliance with stringent regulations (e.g., HIPAA, GDPR) is now more urgent than ever. In this work, we introduce MedCo, the first operational system that enables a group of clinical sites to federate and collectively protect their data in order to share them with external investigators without worrying about security and privacy concerns. MedCo uses (a) collective homomorphic encryption to provide trust decentralization and end-to-end confidentiality protection, and (b) obfuscation techniques to achieve formal notions of privacy, such as differential privacy. A critical feature of MedCo is that it is fully integrated within the i2b2 (Informatics for Integrating Biology and the Bedside) framework, currently used in more than 300 hospitals worldwide. Therefore, it is easily adoptable by clinical sites. We demonstrate MedCo’s practicality by testing it on data from The Cancer Genome Atlas in a simulated network of three institutions. Its performance is comparable to the ones of SHRINE (networked i2b2), which, in contrast, does not provide any data protection guarantee.
000256348 6531_ $$aSecure data-sharing
000256348 6531_ $$ahomomorphic encryption
000256348 6531_ $$adifferential privacy
000256348 6531_ $$ai2b2
000256348 6531_ $$adistributed data
000256348 6531_ $$adecentralized trust
000256348 6531_ $$agenomic privacy
000256348 700__ $$g222090$$aRaisaro, Jean Louis$$0246661
000256348 700__ $$g276461$$aTroncoso-Pastoriza, Juan Ramón$$0250528
000256348 700__ $$g195069$$aMisbach, Mickaël$$0260913
000256348 700__ $$g270625$$aGomes de Sá E Sousa, Joao André$$0253836
000256348 700__ $$aPradervand, Sylvain
000256348 700__ $$aMissiaglia, Edoardo
000256348 700__ $$aMichielin, Olivier
000256348 700__ $$g257875$$aFord, Bryan Alexander$$0249220
000256348 700__ $$0240456$$aHubaux, Jean-Pierre$$g105427
000256348 773__ $$tIEEE/ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS$$j16$$k4$$q1328-1341
000256348 8560_ $$fmickael.misbach@epfl.ch
000256348 8564_ $$zPOSTPRINT$$uhttps://infoscience.epfl.ch/record/256348/files/TCBB2854776.pdf$$s747610
000256348 8564_ $$uhttps://infoscience.epfl.ch/record/256348/files/08410926.pdf$$zFinal$$s1966090
000256348 909C0 $$xU10426$$pLDS$$mjean-pierre.hubaux@epfl.ch$$0252452
000256348 909CO $$qIC$$qGLOBAL_SET$$particle$$ooai:infoscience.epfl.ch:256348
000256348 960__ $$ajean.raisaro@epfl.ch
000256348 961__ $$anoemi.cobolet@epfl.ch
000256348 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000256348 980__ $$aARTICLE
000256348 981__ $$aoverwrite