Palladium(II)-Stabilized Pyridine-2-Diazotates: Synthesis, Structural Characterization, and Cytotoxicity Studies
Tskhovrebov, Alexander G.; Vasileva, Anna A.; Goddard, Richard; Riedel, Tina; Dyson, Paul J.; Mikhaylov, Vladimir N.; Serebryanskaya, Tatiyana V.; Sorokoumov, Viktor N.; Haukka, Matti
2018

Abstract

Well-defined diazotates are scarce. Here we report the synthesis of unprecedented homoleptic palladium(II) diazotate complexes. The palladium(II)-mediated nitrosylation of 2-aminopyridines with NaNO2 results in the formation of metal-stabilized diazotates, which were found to be cytotoxic to human ovarian cancer cells.

Details

Title Palladium(II)-Stabilized Pyridine-2-Diazotates: Synthesis, Structural Characterization, and Cytotoxicity Studies
Author(s) Tskhovrebov, Alexander G. ; Vasileva, Anna A. ; Goddard, Richard ; Riedel, Tina ; Dyson, Paul J. ; Mikhaylov, Vladimir N. ; Serebryanskaya, Tatiyana V. ; Sorokoumov, Viktor N. ; Haukka, Matti
Published in Inorganic Chemistry
Volume 57
Issue 3
Pages 930-934
Date 2018
Keywords
DOI https://doi.org/10.1021/acs.inorgchem.8b00072
Other identifier(s) View record in Web of Science
DOI: https://doi.org/10.1021/acs.inorgchem.8b00072
Laboratories LCOM
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCOM - Laboratory of Organometallic and Medicinal Chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2018-07-11

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