000255970 001__ 255970
000255970 005__ 20180913054521.0
000255970 0247_ $$2doi$$a10.1073/pnas.1800272115
000255970 02470 $$2isi$$a000432120400038
000255970 037__ $$aARTICLE
000255970 245__ $$aCatalytic amino acid production from biomass-derived intermediates
000255970 260__ $$c2018
000255970 269__ $$a2018
000255970 336__ $$aJournal Articles
000255970 520__ $$aAmino acids are the building blocks for protein biosynthesis and find use in myriad industrial applications including in food for humans, in animal feed, and as precursors for bio-based plastics, among others. However, the development of efficient chemical methods to convert abundant and renewable feedstocks into amino acids has been largely unsuccessful to date. To that end, here we report a heterogeneous catalyst that directly transforms lignocellulosic biomass-derived a-hydroxyl acids into a-amino acids, including alanine, leucine, valine, aspartic acid, and phenylalanine in high yields. The reaction follows a dehydrogenation-reductive amination pathway, with dehydrogenation as the rate-determining step. Ruthenium nano-particles supported on carbon nanotubes (Ru/CNT) exhibit exceptional efficiency compared with catalysts based on other metals, due to the unique, reversible enhancement effect of NH3 on Ru in dehydrogenation. Based on the catalytic system, a two-step chemical process was designed to convert glucose into alanine in 43% yield, comparable with the well-established microbial cultivation process, and therefore, the present strategy enables a route for the production of amino acids from renewable feedstocks. Moreover, a conceptual process design employing membrane distillation to facilitate product purification is proposed and validated. Overall, this study offers a rapid and potentially more efficient chemical method to produce amino acids from woody biomass components.
000255970 6531_ $$aamino acids
000255970 6531_ $$aalpha-hydroxyl acids
000255970 6531_ $$aamination
000255970 6531_ $$acatalysis
000255970 6531_ $$aruthenium
000255970 6531_ $$aescherichia-coli
000255970 6531_ $$adirect amination
000255970 6531_ $$alactic-acid
000255970 6531_ $$areductive amination
000255970 6531_ $$ageneral-synthesis
000255970 6531_ $$aconversion
000255970 6531_ $$aalcohols
000255970 6531_ $$aammonia
000255970 6531_ $$alignin
000255970 6531_ $$awater
000255970 700__ $$aDeng, Weiping
000255970 700__ $$aWang, Yunzhu
000255970 700__ $$aZhang, Sui
000255970 700__ $$aGupta, Krishna M.
000255970 700__ $$aHulsey, Max J.
000255970 700__ $$aAsakura, Hiroyuki
000255970 700__ $$aLiu, Lingmei
000255970 700__ $$aHan, Yu
000255970 700__ $$aKarp, Eric M.
000255970 700__ $$aBeckham, Gregg T.
000255970 700__ $$aDyson, Paul J.
000255970 700__ $$aJiang, Jianwen
000255970 700__ $$aTanaka, Tsunehiro
000255970 700__ $$aWang, Ye
000255970 700__ $$aYan, Ning
000255970 773__ $$j115$$k20$$q5093-5098$$tProceedings of The National Academy of Sciences of The United States of America
000255970 8560_ $$fjacqueline.morard@epfl.ch
000255970 909C0 $$0252010$$pLCOM$$xU9
000255970 909CO $$ooai:infoscience.epfl.ch:255970$$pSB$$particle
000255970 960__ $$ajacqueline.morard@epfl.ch
000255970 961__ $$afantin.reichler@epfl.ch
000255970 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000255970 980__ $$aARTICLE
000255970 981__ $$aoverwrite
000255970 981__ $$a255920