000255958 001__ 255958
000255958 005__ 20181203025018.0
000255958 0247_ $$a10.1039/C8NR00663F$$2doi
000255958 02470 $$2DOI$$a10.1039/C8NR00663F
000255958 037__ $$aARTICLE
000255958 245__ $$aMulti-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity
000255958 260__ $$c2018
000255958 269__ $$a2018
000255958 336__ $$aJournal Articles
000255958 520__ $$aMulti-layered single-walled carbon nanotubes, t ermed SWNT@BSA@Au-S-PEG -FA@DOX, which int egrate photothermal therapy with small molecule drug delivery, were prepared using a facile layer-by-layer assembly process. Oxidized and eut single-walled carbon nanotubes (SWNTs) were coated with bovine serum albumin (BSA) to provide abundant active sites for the nucleation of Au seeds, which are subsequently converted into gold nanoparticles (Au NPs) by in situ reduction. The resulting SWNT@BSA@Au material exhibits ideal photothermal properties. Further modification of the nanomaterial with folie acid terminated-polyglycol (FA-PEG-SH) and subsequent loading with doxorubicin (DOX) afford the SWNT@BSA@Au-S-PEG-FA@DOX. The FA terminated PEG endows the material with high water-dispersibility, biocompatibility and cancer cell selectivity. A high drug loading ratio for DOX of up to 5900/o was achieved, with the drug release being pH and temperature dependent, adding to the selectivity of the syste m. High efficacy of the SWNT@BSA@Au-S-PEG­ FA@DOX material, when combined with photothermal therapy (irradiation of the tumor with an 808 nm laser, 1 W cm(-2) for 5 min, 24 h after systemic injection of the nanomedicine), was demonstrated in vivo, resulting in complete tumor eradication. Remarkably, the side effects are negligible with only minor damage to normal tissues including the liver and kidneys being observed.
000255958 700__ $$aWang, Daquan
000255958 700__ $$aMeng, Lingjie
000255958 700__ $$aFei, Zhaofu
000255958 700__ $$aHou, Chen
000255958 700__ $$aLong, Jiangang
000255958 700__ $$aZeng, Leli
000255958 700__ $$aDyson, Paul J.
000255958 700__ $$aHuang, Peng
000255958 773__ $$tNanoscale$$j10$$k18$$q8536-8546
000255958 8560_ $$fjacqueline.morard@epfl.ch
000255958 909C0 $$xU9$$pLCOM$$0252010
000255958 909CO $$pSB$$particle$$ooai:infoscience.epfl.ch:255958
000255958 960__ $$ajacqueline.morard@epfl.ch
000255958 961__ $$afantin.reichler@epfl.ch
000255958 973__ $$aEPFL$$sPUBLISHED$$rREVIEWED
000255958 980__ $$aARTICLE
000255958 981__ $$aoverwrite