000255671 001__ 255671
000255671 005__ 20190507143842.0
000255671 0247_ $$a10.1016/j.snb.2018.02.036$$2doi
000255671 02470 $$2DOI$$a10.1016/j.snb.2018.02.036
000255671 037__ $$aARTICLE
000255671 245__ $$aGraphene nanowalls for high-performance chemotherapeutic drug sensing and anti-fouling properties
000255671 260__ $$c2018-06-01
000255671 269__ $$a2018-06-01
000255671 336__ $$aJournal Articles
000255671 520__ $$aImproved sensitivity and continuous monitoring of therapeutic compounds are two of the most highlighted concerns for the treatment of malignant diseases, such as cancer. We demonstrated ultrasensitive screening of etoposide, a therapeutic compound widely-used in chemotherapy, achieved at low concentrations via the implementation of optimized graphene nanowalls. The developed graphene nanowalls displayed excellent electrochemical sensing capabilities in the etoposide detection with regards to the drug therapeutic window, without any post-transfer procedures or any further surface treatment. The direct, catalyst-free, vertical growth of graphene nanostructures forming a honeycomb network on the substrate, was presented involving three different substrates and implementing different growth parameters. SEM, TEM and Raman spectroscopy techniques were implemented to verify the results. The configuration that demonstrated the overall best performance in the sensing of electroactive compounds was selected and utilized for the effective screening of the drug resulting in a detection limit down to 4.36 nM. Moreover, the suggested sensors demonstrated excellent anti-fouling properties by removing in average the 97.44 ± 2.7% of first etoposide peak and 100% of second peak after 3 cycles of cleaning in blank buffer; bringing solutions to a common problem of electroactive compound screening and highlighting the sensing capabilities for continuous monitoring of the drug.
000255671 536__ $$aH2020$$cERC Cybercare 669354
000255671 536__ $$aEU funding$$cMarie-Curie Initial Training Network PROSENSE 317420
000255671 700__ $$g234004$$0247383$$aTzouvadaki, Ioulia
000255671 700__ $$aAliakbarinodehi, Nima
000255671 700__ $$aDávila Pineda, Diana
000255671 700__ $$aDe Micheli, Giovanni
000255671 700__ $$aCarrara, Sandro
000255671 773__ $$j262$$tSensors and Actuators B: Chemical$$q395-403
000255671 8560_ $$fcarole.burget@epfl.ch
000255671 909C0 $$pLSI1$$manil.leblebici@epfl.ch$$mchristina.govoni@epfl.ch$$0252283$$xU11140
000255671 909CO $$pSTI$$pIC$$particle$$ooai:infoscience.epfl.ch:255671
000255671 960__ $$aanil.leblebici@epfl.ch
000255671 961__ $$aalain.borel@epfl.ch
000255671 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000255671 980__ $$aARTICLE
000255671 981__ $$aoverwrite