000255592 001__ 255592
000255592 005__ 20190619220032.0
000255592 037__ $$aCONF
000255592 245__ $$aA novel electrochemical sensor for non-invasive monitoring of lithium levels in mood disorders
000255592 260__ $$c2018-07-21
000255592 269__ $$a2018-07-21
000255592 300__ $$a4
000255592 336__ $$aConference Papers
000255592 500__ $$aERC Cybercare 669354
000255592 520__ $$aLithium is the main drug for the treatment of mood disorders. Due to its narrow therapeutic window, Therapeutic Drug Monitoring (TDM) is a norm during therapy in order to avoid adverse effects. Consequently, patients are obliged to frequent check-ups in hospitals to determine their serum concentration and optimize accordingly the drug dose. Wearable sensors have attracted a growing interest in the research community in recent years owing to their promising impact in personalized healthcare. In particular, sweat diagnosis has seen an enormous expansion and is currently entering the market thanks to the large availability and simple collection of this fluid. In this paper a novel approach for non-invasive decentralized monitoring of lithium drug concentration through sweat analysis is proposed for the first time. An all-solid-state Ion- Selective Electrode (ISE) with a nanostructured Solid-Contact (SC) is used to detect lithium ions in sweat. The sensor offers near-Nernstian behaviour (57.6±2.1 mV/decade) in the concentration range of interest. In addition, it shows fast response (15-30 s), good reversibility and small potential drift over time. A wide pH stability window (pH 4-12) is also proved.
000255592 6531_ $$abipolar disorder;
000255592 6531_ $$asweat diagnosis;
000255592 6531_ $$alithium drug;
000255592 6531_ $$adrug monitoring;
000255592 6531_ $$apersonalized healthcare;
000255592 6531_ $$awearable electrochemical sensors
000255592 700__ $$g267921$$aCriscuolo, Francesca$$0249992
000255592 700__ $$g198935$$aTaurino, Irene$$0245317
000255592 700__ $$aCarrara, Sandro$$0242413$$g182237
000255592 700__ $$0240269$$aDe Micheli, Giovanni$$g167918
000255592 7112_ $$dJuly 17-21, 2018$$cHonolulu, Hawaii, USA$$a40th International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
000255592 773__ $$tProceedings of the 40th International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
000255592 8560_ $$fcarole.burget@epfl.ch
000255592 8564_ $$uhttps://infoscience.epfl.ch/record/255592/files/EMBC_Submission.pdf$$s583083
000255592 909C0 $$xU11140$$pLSI1$$manil.leblebici@epfl.ch$$mchristina.govoni@epfl.ch$$0252283
000255592 909C0 $$xU11189$$pLSI2$$manil.leblebici@epfl.ch$$mchristina.govoni@epfl.ch$$0252284
000255592 909CO $$qGLOBAL_SET$$pconf$$pSTI$$pIC$$ooai:infoscience.epfl.ch:255592
000255592 960__ $$aanil.leblebici@epfl.ch
000255592 961__ $$aalain.borel@epfl.ch
000255592 973__ $$aEPFL$$rREVIEWED
000255592 980__ $$aCONF
000255592 981__ $$aoverwrite