Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
Malta, Tathiane M.; Sokolov, Artem; Gentles, Andrew J.; Burzykowski, Tomasz; Poisson, Laila; Weinstein, John N.; Kamińska, Bożena; Huelsken, Joerg; Omberg, Larsson; Gevaert, Olivier; Colaprico, Antonio; Czerwińska, Patrycja; Mazurek, Sylwia; Mishra, Lopa; Heyn, Holger; Krasnitz, Alex; Godwin, Andrew K.; Lazar, Alexander J.; Stuart, Joshua M.; Hoadley, Katherine A.; Laird, Peter W.; Noushmehr, Houtan; Wiznerowicz, Maciej; Caesar-Johnson, Samantha J.; Demchok, John A.; Felau, Ina; Kasapi, Melpomeni; Ferguson, Martin L.; Hutter, Carolyn M.; Sofia, Heidi J.; Tarnuzzer, Roy; Wang, Zhining; Yang, Liming; Zenklusen, Jean C.; Zhang, Jiashan (Julia); Chudamani, Sudha; Liu, Jia; Lolla, Laxmi; Naresh, Rashi; Pihl, Todd; Sun, Qiang; Wan, Yunhu; Wu, Ye; Cho, Juok; DeFreitas, Timothy; Frazer, Scott; Gehlenborg, Nils; Getz, Gad; Heiman, David I.; Kim, Jaegil; Lawrence, Michael S.; Lin, Pei; Meier, Sam; Noble, Michael S.; Saksena, Gordon; Voet, Doug; Zhang, Hailei; Bernard, Brady; Chambwe, Nyasha; Dhankani, Varsha; Knijnenburg, Theo; Kramer, Roger; Leinonen, Kalle; Liu, Yuexin; Miller, Michael; Reynolds, Sheila; Shmulevich, Ilya; Thorsson, Vesteinn; Zhang, Wei; Akbani, Rehan; Broom, Bradley M.; Hegde, Apurva M.; Ju, Zhenlin; Kanchi, Rupa S.; Korkut, Anil; Li, Jun; Liang, Han; Ling, Shiyun; Liu, Wenbin; Lu, Yiling; Mills, Gordon B.; Ng, Kwok-Shing; Rao, Arvind; Ryan, Michael; Wang, Jing; Zhang, Jiexin; Abeshouse, Adam; Armenia, Joshua; Chakravarty, Debyani; Chatila, Walid K.; de Bruijn, Ino; Gao, Jianjiong; Gross, Benjamin E.; Heins, Zachary J.; Kundra, Ritika; La, Konnor; Ladanyi, Marc; Luna, Augustin; Nissan, Moriah G.; Ochoa, Angelica; Phillips, Sarah M.; Reznik, Ed; Sanchez-Vega, Francisco; Sander, Chris; Schultz, Nikolaus; Sheridan, Robert; Sumer, S. Onur; Sun, Yichao; Taylor, Barry S.; Wang, Jioajiao; Zhang, Hongxin; Anur, Pavana; Peto, Myron; Spellman, Paul; Benz, Christopher; Wong, Christopher K.; Yau, Christina; Hayes, D. Neil; Parker, Joel S.; Wilkerson, Matthew D.; Ally, Adrian; Balasundaram, Miruna; Bowlby, Reanne; Brooks, Denise; Carlsen, Rebecca; Chuah, Eric; Dhalla, Noreen; Holt, Robert; Jones, Steven J.M.; Kasaian, Katayoon; Lee, Darlene; Ma, Yussanne; Marra, Marco A.; Mayo, Michael; Moore, Richard A.; Mungall, Andrew J.; Mungall, Karen; Robertson, A. Gordon; Sadeghi, Sara; Schein, Jacqueline E.; Sipahimalani, Payal; Tam, Angela; Thiessen, Nina; Tse, Kane; Wong, Tina; Berger, Ashton C.; Beroukhim, Rameen; Cherniack, Andrew D.; Cibulskis, Carrie; Gabriel, Stacey B.; Gao, Galen F.; Ha, Gavin; Meyerson, Matthew; Schumacher, Steven E.; Shih, Juliann; Kucherlapati, Melanie H.; Kucherlapati, Raju S.; Baylin, Stephen; Cope, Leslie; Danilova, Ludmila; Bootwalla, Moiz S.; Lai, Phillip H.; Maglinte, Dennis T.; Van Den Berg, David J.; Weisenberger, Daniel J.; Auman, J. Todd; Balu, Saianand; Bodenheimer, Tom; Fan, Cheng; Hoyle, Alan P.; Jefferys, Stuart R.; Jones, Corbin D.; Meng, Shaowu; Mieczkowski, Piotr A.; Mose, Lisle E.; Perou, Amy H.; Perou, Charles M.; Roach, Jeffrey; Shi, Yan; Simons, Janae V.; Skelly, Tara; Soloway, Matthew G.; Tan, Donghui; Veluvolu, Umadevi; Fan, Huihui; Hinoue, Toshinori; Shen, Hui; Zhou, Wanding; Bellair, Michelle; Chang, Kyle; Covington, Kyle; Creighton, Chad J.; Dinh, Huyen; Doddapaneni, HarshaVardhan; Donehower, Lawrence A.; Drummond, Jennifer; Gibbs, Richard A.; Glenn, Robert; Hale, Walker; Han, Yi; Hu, Jianhong; Korchina, Viktoriya; Lee, Sandra; Lewis, Lora; Li, Wei; Liu, Xiuping; Morgan, Margaret; Morton, Donna; Muzny, Donna; Santibanez, Jireh; Sheth, Margi; Shinbrot, Eve; Wang, Linghua; Wang, Min; Wheeler, David A.; Xi, Liu; Zhao, Fengmei; Hess, Julian; Appelbaum, Elizabeth L.; Bailey, Matthew; Cordes, Matthew G.; Ding, Li; Fronick, Catrina C.; Fulton, Lucinda A.; Fulton, Robert S.; Kandoth, Cyriac; Mardis, Elaine R.; McLellan, Michael D.; Miller, Christopher A.; Schmidt, Heather K.; Wilson, Richard K.; Crain, Daniel; Curley, Erin; Gardner, Johanna; Lau, Kevin; Mallery, David; Morris, Scott; Paulauskis, Joseph; Penny, Robert; Shelton, Candace; Shelton, Troy; Sherman, Mark; Thompson, Eric; Yena, Peggy; Bowen, Jay; Gastier-Foster, Julie M.; Gerken, Mark; Leraas, Kristen M.; Lichtenberg, Tara M.; Ramirez, Nilsa C.; Wise, Lisa; Zmuda, Erik; Corcoran, Niall; Costello, Tony; Hovens, Christopher; Carvalho, Andre L.; de Carvalho, Ana C.; Fregnani, José H.; Longatto-Filho, Adhemar; Reis, Rui M.; Scapulatempo-Neto, Cristovam; Silveira, Henrique C.S.; Vidal, Daniel O.; Burnette, Andrew; Eschbacher, Jennifer; Hermes, Beth; Noss, Ardene; Singh, Rosy; Anderson, Matthew L.; Castro, Patricia D.; Ittmann, Michael; Huntsman, David; Kohl, Bernard; Le, Xuan; Thorp, Richard; Andry, Chris; Duffy, Elizabeth R.; Lyadov, Vladimir; Paklina, Oxana; Setdikova, Galiya; Shabunin, Alexey; Tavobilov, Mikhail; McPherson, Christopher; Warnick, Ronald; Berkowitz, Ross; Cramer, Daniel; Feltmate, Colleen; Horowitz, Neil; Kibel, Adam; Muto, Michael; Raut, Chandrajit P.; Malykh, Andrei; Barnholtz-Sloan, Jill S.; Barrett, Wendi; Devine, Karen; Fulop, Jordonna; Ostrom, Quinn T.; Shimmel, Kristen; Wolinsky, Yingli; Sloan, Andrew E.; De Rose, Agostino; Giuliante, Felice; Goodman, Marc; Karlan, Beth Y.; Hagedorn, Curt H.; Eckman, John; Harr, Jodi; Myers, Jerome; Tucker, Kelinda; Zach, Leigh Anne; Deyarmin, Brenda; Hu, Hai; Kvecher, Leonid; Larson, Caroline; Mural, Richard J.; Somiari, Stella; Vicha, Ales; Zelinka, Tomas; Bennett, Joseph; Iacocca, Mary; Rabeno, Brenda; Swanson, Patricia; Latour, Mathieu; Lacombe, Louis; Têtu, Bernard; Bergeron, Alain; McGraw, Mary; Staugaitis, Susan M.; Chabot, John; Hibshoosh, Hanina; Sepulveda, Antonia; Su, Tao; Wang, Timothy; Potapova, Olga; Voronina, Olga; Desjardins, Laurence; Mariani, Odette; Roman-Roman, Sergio; Sastre, Xavier; Stern, Marc-Henri; Cheng, Feixiong; Signoretti, Sabina; Berchuck, Andrew; Bigner, Darell; Lipp, Eric; Marks, Jeffrey; McCall, Shannon; McLendon, Roger; Secord, Angeles; Sharp, Alexis; Behera, Madhusmita; Brat, Daniel J.; Chen, Amy; Delman, Keith; Force, Seth; Khuri, Fadlo; Magliocca, Kelly; Maithel, Shishir; Olson, Jeffrey J.; Owonikoko, Taofeek; Pickens, Alan; Ramalingam, Suresh; Shin, Dong M.; Sica, Gabriel; Van Meir, Erwin G.; Zhang, Hongzheng; Eijckenboom, Wil; Gillis, Ad; Korpershoek, Esther; Looijenga, Leendert; Oosterhuis, Wolter; Stoop, Hans; van Kessel, Kim E.; Zwarthoff, Ellen C.; Calatozzolo, Chiara; Cuppini, Lucia; Cuzzubbo, Stefania; DiMeco, Francesco; Finocchiaro, Gaetano; Mattei, Luca; Perin, Alessandro; Pollo, Bianca; Chen, Chu; Houck, John; Lohavanichbutr, Pawadee; Hartmann, Arndt; Stoehr, Christine; Stoehr, Robert; Taubert, Helge; Wach, Sven; Wullich, Bernd; Kycler, Witold; Murawa, Dawid; Chung, Ki; Edenfield, W. Jeffrey; Martin, Julie; Baudin, Eric; Bubley, Glenn; Bueno, Raphael; De Rienzo, Assunta; Richards, William G.; Kalkanis, Steven; Mikkelsen, Tom; Scarpace, Lisa; Girard, Nicolas; Aymerich, Marta; Campo, Elias; Giné, Eva; Guillermo, Armando López; Van Bang, Nguyen; Hanh, Phan Thi; Phu, Bui Duc; Tang, Yufang; Colman, Howard; Evason, Kimberley; Dottino, Peter R.; Martignetti, John A.; Gabra, Hani; Juhl, Hartmut; Akeredolu, Teniola; Stepa, Serghei; Hoon, Dave; Ahn, Keunsoo; Kang, Koo Jeong; Beuschlein, Felix; Breggia, Anne; Birrer, Michael; Bell, Debra; Borad, Mitesh; Bryce, Alan H.; Castle, Erik; Chandan, Vishal; Cheville, John; Copland, John A.; Farnell, Michael; Flotte, Thomas; Giama, Nasra; Ho, Thai; Kendrick, Michael; Kocher, Jean-Pierre; Kopp, Karla; Moser, Catherine; Nagorney, David; O’Brien, Daniel; O’Neill, Brian Patrick; Patel, Tushar; Petersen, Gloria; Que, Florencia; Rivera, Michael; Roberts, Lewis; Smallridge, Robert; Smyrk, Thomas; Stanton, Melissa; Thompson, R. Houston; Torbenson, Michael; Yang, Ju Dong; Zhang, Lizhi; Brimo, Fadi; Ajani, Jaffer A.; Gonzalez, Ana Maria Angulo; Behrens, Carmen; Bondaruk, Jolanta; Broaddus, Russell; Czerniak, Bogdan; Esmaeli, Bita; Fujimoto, Junya; Gershenwald, Jeffrey; Guo, Charles; Logothetis, Christopher; Meric-Bernstam, Funda; Moran, Cesar; Ramondetta, Lois; Rice, David; Sood, Anil; Tamboli, Pheroze; Thompson, Timothy; Troncoso, Patricia; Tsao, Anne; Wistuba, Ignacio; Carter, Candace; Haydu, Lauren; Hersey, Peter; Jakrot, Valerie; Kakavand, Hojabr; Kefford, Richard; Lee, Kenneth; Long, Georgina; Mann, Graham; Quinn, Michael; Saw, Robyn; Scolyer, Richard; Shannon, Kerwin; Spillane, Andrew; Stretch, Jonathan; Synott, Maria; Thompson, John; Wilmott, James; Al-Ahmadie, Hikmat; Chan, Timothy A.; Ghossein, Ronald; Gopalan, Anuradha; Levine, Douglas A.; Reuter, Victor; Singer, Samuel; Singh, Bhuvanesh; Tien, Nguyen Viet; Broudy, Thomas; Mirsaidi, Cyrus; Nair, Praveen; Drwiega, Paul; Miller, Judy; Smith, Jennifer; Zaren, Howard; Park, Joong-Won; Hung, Nguyen Phi; Kebebew, Electron; Linehan, W. Marston; Metwalli, Adam R.; Pacak, Karel; Pinto, Peter A.; Schiffman, Mark; Schmidt, Laura S.; Vocke, Cathy D.; Wentzensen, Nicolas; Worrell, Robert; Yang, Hannah; Moncrieff, Marc; Goparaju, Chandra; Melamed, Jonathan; Pass, Harvey; Botnariuc, Natalia; Caraman, Irina; Cernat, Mircea; Chemencedji, Inga; Clipca, Adrian; Doruc, Serghei; Gorincioi, Ghenadie; Mura, Sergiu; Pirtac, Maria; Stancul, Irina; Tcaciuc, Diana; Albert, Monique; Alexopoulou, Iakovina; Arnaout, Angel; Bartlett, John; Engel, Jay; Gilbert, Sebastien; Parfitt, Jeremy; Sekhon, Harman; Thomas, George; Rassl, Doris M.; Rintoul, Robert C.; Bifulco, Carlo; Tamakawa, Raina; Urba, Walter; Hayward, Nicholas; Timmers, Henri; Antenucci, Anna; Facciolo, Francesco; Grazi, Gianluca; Marino, Mirella; Merola, Roberta; de Krijger, Ronald; Gimenez-Roqueplo, Anne-Paule; Piché, Alain; Chevalier, Simone; McKercher, Ginette; Birsoy, Kivanc; Barnett, Gene; Brewer, Cathy; Farver, Carol; Naska, Theresa; Pennell, Nathan A.; Raymond, Daniel; Schilero, Cathy; Smolenski, Kathy; Williams, Felicia; Morrison, Carl; Borgia, Jeffrey A.; Liptay, Michael J.; Pool, Mark; Seder, Christopher W.; Junker, Kerstin; Dinkin, Mikhail; Manikhas, George; Alvaro, Domenico; Bragazzi, Maria Consiglia; Cardinale, Vincenzo; Carpino, Guido; Gaudio, Eugenio; Chesla, David; Cottingham, Sandra; Dubina, Michael; Moiseenko, Fedor; Dhanasekaran, Renumathy; Becker, Karl-Friedrich; Janssen, Klaus-Peter; Slotta-Huspenina, Julia; Abdel-Rahman, Mohamed H.; Aziz, Dina; Bell, Sue; Cebulla, Colleen M.; Davis, Amy; Duell, Rebecca; Elder, J. Bradley; Hilty, Joe; Kumar, Bahavna; Lang, James; Lehman, Norman L.; Mandt, Randy; Nguyen, Phuong; Pilarski, Robert; Rai, Karan; Schoenfield, Lynn; Senecal, Kelly; Wakely, Paul; Hansen, Paul; Lechan, Ronald; Powers, James; Tischler, Arthur; Grizzle, William E.; Sexton, Katherine C.; Kastl, Alison; Henderson, Joel; Porten, Sima; Waldmann, Jens; Fassnacht, Martin; Asa, Sylvia L.; Schadendorf, Dirk; Couce, Marta; Graefen, Markus; Huland, Hartwig; Sauter, Guido; Schlomm, Thorsten; Simon, Ronald; Tennstedt, Pierre; Olabode, Oluwole; Nelson, Mark; Bathe, Oliver; Carroll, Peter R.; Chan, June M.; Disaia, Philip; Glenn, Pat; Kelley, Robin K.; Landen, Charles N.; Phillips, Joanna; Prados, Michael; Simko, Jeffry; Smith-McCune, Karen; VandenBerg, Scott; Roggin, Kevin; Fehrenbach, Ashley; Kendler, Ady; Sifri, Suzanne; Steele, Ruth; Jimeno, Antonio; Carey, Francis; Forgie, Ian; Mannelli, Massimo; Carney, Michael; Hernandez, Brenda; Campos, Benito; Herold-Mende, Christel; Jungk, Christin; Unterberg, Andreas; von Deimling, Andreas; Bossler, Aaron; Galbraith, Joseph; Jacobus, Laura; Knudson, Michael; Knutson, Tina; Ma, Deqin; Milhem, Mohammed; Sigmund, Rita; Madan, Rashna; Rosenthal, Howard G.; Adebamowo, Clement; Adebamowo, Sally N.; Boussioutas, Alex; Beer, David; Giordano, Thomas; Mes-Masson, Anne-Marie; Saad, Fred; Bocklage, Therese; Landrum, Lisa; Mannel, Robert; Moore, Kathleen; Moxley, Katherine; Postier, Russel; Walker, Joan; Zuna, Rosemary; Feldman, Michael; Valdivieso, Federico; Dhir, Rajiv; Luketich, James; Pinero, Edna M. Mora; Quintero-Aguilo, Mario; Carlotti, Carlos Gilberto; Dos Santos, Jose Sebastião; Kemp, Rafael; Sankarankuty, Ajith; Tirapelli, Daniela; Catto, James; Agnew, Kathy; Swisher, Elizabeth; Creaney, Jenette; Robinson, Bruce; Shelley, Carl Simon; Godwin, Eryn M.; Kendall, Sara; Shipman, Cassaundra; Bradford, Carol; Carey, Thomas; Haddad, Andrea; Moyer, Jeffey; Peterson, Lisa; Prince, Mark; Rozek, Laura; Wolf, Gregory; Bowman, Rayleen; Fong, Kwun M.; Yang, Ian; Korst, Robert; Rathmell, W. Kimryn; Fantacone-Campbell, J. Leigh; Hooke, Jeffrey A.; Kovatich, Albert J.; Shriver, Craig D.; DiPersio, John; Drake, Bettina; Govindan, Ramaswamy; Heath, Sharon; Ley, Timothy; Van Tine, Brian; Westervelt, Peter; Rubin, Mark A.; Lee, Jung Il; Aredes, Natália D.; Mariamidze, Armaz
2018
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Résumé
Cancer progression involves the gradual loss of a differentiated phenotype and acquisition of progenitor and stem-cell-like features. Here, we provide novel stemness indices for assessing the degree of oncogenic dedifferentiation. We used an innovative one-class logistic regression (OCLR) machine-learning algorithm to extract transcriptomic and epigenetic feature sets derived from non-transformed pluripotent stem cells and their differentiated progeny. Using OCLR, we were able to identify previously undiscovered biological mechanisms associated with the dedifferentiated oncogenic state. Analyses of the tumor microenvironment revealed unanticipated correlation of cancer stemness with immune checkpoint expression and infiltrating immune cells. We found that the dedifferentiated oncogenic phenotype was generally most prominent in metastatic tumors. Application of our stemness indices to single-cell data revealed patterns of intra-tumor molecular heterogeneity. Finally, the indices allowed for the identification of novel targets and possible targeted therapies aimed at tumor differentiation.
Détails
Titre
Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
Auteur(s)
Malta, Tathiane M. ; Sokolov, Artem ; Gentles, Andrew J. ; Burzykowski, Tomasz ; Poisson, Laila ; Weinstein, John N. ; Kamińska, Bożena ; Huelsken, Joerg ; Omberg, Larsson ; Gevaert, Olivier ; Colaprico, Antonio ; Czerwińska, Patrycja ; Mazurek, Sylwia ; Mishra, Lopa ; Heyn, Holger ; Krasnitz, Alex ; Godwin, Andrew K. ; Lazar, Alexander J. ; Stuart, Joshua M. ; Hoadley, Katherine A. ; Laird, Peter W. ; Noushmehr, Houtan ; Wiznerowicz, Maciej ; Caesar-Johnson, Samantha J. ; Demchok, John A. ; Felau, Ina ; Kasapi, Melpomeni ; Ferguson, Martin L. ; Hutter, Carolyn M. ; Sofia, Heidi J. ; Tarnuzzer, Roy ; Wang, Zhining ; Yang, Liming ; Zenklusen, Jean C. ; Zhang, Jiashan (Julia) ; Chudamani, Sudha ; Liu, Jia ; Lolla, Laxmi ; Naresh, Rashi ; Pihl, Todd ; Sun, Qiang ; Wan, Yunhu ; Wu, Ye ; Cho, Juok ; DeFreitas, Timothy ; Frazer, Scott ; Gehlenborg, Nils ; Getz, Gad ; Heiman, David I. ; Kim, Jaegil ; Lawrence, Michael S. ; Lin, Pei ; Meier, Sam ; Noble, Michael S. ; Saksena, Gordon ; Voet, Doug ; Zhang, Hailei ; Bernard, Brady ; Chambwe, Nyasha ; Dhankani, Varsha ; Knijnenburg, Theo ; Kramer, Roger ; Leinonen, Kalle ; Liu, Yuexin ; Miller, Michael ; Reynolds, Sheila ; Shmulevich, Ilya ; Thorsson, Vesteinn ; Zhang, Wei ; Akbani, Rehan ; Broom, Bradley M. ; Hegde, Apurva M. ; Ju, Zhenlin ; Kanchi, Rupa S. ; Korkut, Anil ; Li, Jun ; Liang, Han ; Ling, Shiyun ; Liu, Wenbin ; Lu, Yiling ; Mills, Gordon B. ; Ng, Kwok-Shing ; Rao, Arvind ; Ryan, Michael ; Wang, Jing ; Zhang, Jiexin ; Abeshouse, Adam ; Armenia, Joshua ; Chakravarty, Debyani ; Chatila, Walid K. ; de Bruijn, Ino ; Gao, Jianjiong ; Gross, Benjamin E. ; Heins, Zachary J. ; Kundra, Ritika ; La, Konnor ; Ladanyi, Marc ; Luna, Augustin ; Nissan, Moriah G. ; Ochoa, Angelica ; Phillips, Sarah M. ; Reznik, Ed ; Sanchez-Vega, Francisco ; Sander, Chris ; Schultz, Nikolaus ; Sheridan, Robert ; Sumer, S. Onur ; Sun, Yichao ; Taylor, Barry S. ; Wang, Jioajiao ; Zhang, Hongxin ; Anur, Pavana ; Peto, Myron ; Spellman, Paul ; Benz, Christopher ; Wong, Christopher K. ; Yau, Christina ; Hayes, D. Neil ; Parker, Joel S. ; Wilkerson, Matthew D. ; Ally, Adrian ; Balasundaram, Miruna ; Bowlby, Reanne ; Brooks, Denise ; Carlsen, Rebecca ; Chuah, Eric ; Dhalla, Noreen ; Holt, Robert ; Jones, Steven J.M. ; Kasaian, Katayoon ; Lee, Darlene ; Ma, Yussanne ; Marra, Marco A. ; Mayo, Michael ; Moore, Richard A. ; Mungall, Andrew J. ; Mungall, Karen ; Robertson, A. Gordon ; Sadeghi, Sara ; Schein, Jacqueline E. ; Sipahimalani, Payal ; Tam, Angela ; Thiessen, Nina ; Tse, Kane ; Wong, Tina ; Berger, Ashton C. ; Beroukhim, Rameen ; Cherniack, Andrew D. ; Cibulskis, Carrie ; Gabriel, Stacey B. ; Gao, Galen F. ; Ha, Gavin ; Meyerson, Matthew ; Schumacher, Steven E. ; Shih, Juliann ; Kucherlapati, Melanie H. ; Kucherlapati, Raju S. ; Baylin, Stephen ; Cope, Leslie ; Danilova, Ludmila ; Bootwalla, Moiz S. ; Lai, Phillip H. ; Maglinte, Dennis T. ; Van Den Berg, David J. ; Weisenberger, Daniel J. ; Auman, J. Todd ; Balu, Saianand ; Bodenheimer, Tom ; Fan, Cheng ; Hoyle, Alan P. ; Jefferys, Stuart R. ; Jones, Corbin D. ; Meng, Shaowu ; Mieczkowski, Piotr A. ; Mose, Lisle E. ; Perou, Amy H. ; Perou, Charles M. ; Roach, Jeffrey ; Shi, Yan ; Simons, Janae V. ; Skelly, Tara ; Soloway, Matthew G. ; Tan, Donghui ; Veluvolu, Umadevi ; Fan, Huihui ; Hinoue, Toshinori ; Shen, Hui ; Zhou, Wanding ; Bellair, Michelle ; Chang, Kyle ; Covington, Kyle ; Creighton, Chad J. ; Dinh, Huyen ; Doddapaneni, HarshaVardhan ; Donehower, Lawrence A. ; Drummond, Jennifer ; Gibbs, Richard A. ; Glenn, Robert ; Hale, Walker ; Han, Yi ; Hu, Jianhong ; Korchina, Viktoriya ; Lee, Sandra ; Lewis, Lora ; Li, Wei ; Liu, Xiuping ; Morgan, Margaret ; Morton, Donna ; Muzny, Donna ; Santibanez, Jireh ; Sheth, Margi ; Shinbrot, Eve ; Wang, Linghua ; Wang, Min ; Wheeler, David A. ; Xi, Liu ; Zhao, Fengmei ; Hess, Julian ; Appelbaum, Elizabeth L. ; Bailey, Matthew ; Cordes, Matthew G. ; Ding, Li ; Fronick, Catrina C. ; Fulton, Lucinda A. ; Fulton, Robert S. ; Kandoth, Cyriac ; Mardis, Elaine R. ; McLellan, Michael D. ; Miller, Christopher A. ; Schmidt, Heather K. ; Wilson, Richard K. ; Crain, Daniel ; Curley, Erin ; Gardner, Johanna ; Lau, Kevin ; Mallery, David ; Morris, Scott ; Paulauskis, Joseph ; Penny, Robert ; Shelton, Candace ; Shelton, Troy ; Sherman, Mark ; Thompson, Eric ; Yena, Peggy ; Bowen, Jay ; Gastier-Foster, Julie M. ; Gerken, Mark ; Leraas, Kristen M. ; Lichtenberg, Tara M. ; Ramirez, Nilsa C. ; Wise, Lisa ; Zmuda, Erik ; Corcoran, Niall ; Costello, Tony ; Hovens, Christopher ; Carvalho, Andre L. ; de Carvalho, Ana C. ; Fregnani, José H. ; Longatto-Filho, Adhemar ; Reis, Rui M. ; Scapulatempo-Neto, Cristovam ; Silveira, Henrique C.S. ; Vidal, Daniel O. ; Burnette, Andrew ; Eschbacher, Jennifer ; Hermes, Beth ; Noss, Ardene ; Singh, Rosy ; Anderson, Matthew L. ; Castro, Patricia D. ; Ittmann, Michael ; Huntsman, David ; Kohl, Bernard ; Le, Xuan ; Thorp, Richard ; Andry, Chris ; Duffy, Elizabeth R. ; Lyadov, Vladimir ; Paklina, Oxana ; Setdikova, Galiya ; Shabunin, Alexey ; Tavobilov, Mikhail ; McPherson, Christopher ; Warnick, Ronald ; Berkowitz, Ross ; Cramer, Daniel ; Feltmate, Colleen ; Horowitz, Neil ; Kibel, Adam ; Muto, Michael ; Raut, Chandrajit P. ; Malykh, Andrei ; Barnholtz-Sloan, Jill S. ; Barrett, Wendi ; Devine, Karen ; Fulop, Jordonna ; Ostrom, Quinn T. ; Shimmel, Kristen ; Wolinsky, Yingli ; Sloan, Andrew E. ; De Rose, Agostino ; Giuliante, Felice ; Goodman, Marc ; Karlan, Beth Y. ; Hagedorn, Curt H. ; Eckman, John ; Harr, Jodi ; Myers, Jerome ; Tucker, Kelinda ; Zach, Leigh Anne ; Deyarmin, Brenda ; Hu, Hai ; Kvecher, Leonid ; Larson, Caroline ; Mural, Richard J. ; Somiari, Stella ; Vicha, Ales ; Zelinka, Tomas ; Bennett, Joseph ; Iacocca, Mary ; Rabeno, Brenda ; Swanson, Patricia ; Latour, Mathieu ; Lacombe, Louis ; Têtu, Bernard ; Bergeron, Alain ; McGraw, Mary ; Staugaitis, Susan M. ; Chabot, John ; Hibshoosh, Hanina ; Sepulveda, Antonia ; Su, Tao ; Wang, Timothy ; Potapova, Olga ; Voronina, Olga ; Desjardins, Laurence ; Mariani, Odette ; Roman-Roman, Sergio ; Sastre, Xavier ; Stern, Marc-Henri ; Cheng, Feixiong ; Signoretti, Sabina ; Berchuck, Andrew ; Bigner, Darell ; Lipp, Eric ; Marks, Jeffrey ; McCall, Shannon ; McLendon, Roger ; Secord, Angeles ; Sharp, Alexis ; Behera, Madhusmita ; Brat, Daniel J. ; Chen, Amy ; Delman, Keith ; Force, Seth ; Khuri, Fadlo ; Magliocca, Kelly ; Maithel, Shishir ; Olson, Jeffrey J. ; Owonikoko, Taofeek ; Pickens, Alan ; Ramalingam, Suresh ; Shin, Dong M. ; Sica, Gabriel ; Van Meir, Erwin G. ; Zhang, Hongzheng ; Eijckenboom, Wil ; Gillis, Ad ; Korpershoek, Esther ; Looijenga, Leendert ; Oosterhuis, Wolter ; Stoop, Hans ; van Kessel, Kim E. ; Zwarthoff, Ellen C. ; Calatozzolo, Chiara ; Cuppini, Lucia ; Cuzzubbo, Stefania ; DiMeco, Francesco ; Finocchiaro, Gaetano ; Mattei, Luca ; Perin, Alessandro ; Pollo, Bianca ; Chen, Chu ; Houck, John ; Lohavanichbutr, Pawadee ; Hartmann, Arndt ; Stoehr, Christine ; Stoehr, Robert ; Taubert, Helge ; Wach, Sven ; Wullich, Bernd ; Kycler, Witold ; Murawa, Dawid ; Chung, Ki ; Edenfield, W. Jeffrey ; Martin, Julie ; Baudin, Eric ; Bubley, Glenn ; Bueno, Raphael ; De Rienzo, Assunta ; Richards, William G. ; Kalkanis, Steven ; Mikkelsen, Tom ; Scarpace, Lisa ; Girard, Nicolas ; Aymerich, Marta ; Campo, Elias ; Giné, Eva ; Guillermo, Armando López ; Van Bang, Nguyen ; Hanh, Phan Thi ; Phu, Bui Duc ; Tang, Yufang ; Colman, Howard ; Evason, Kimberley ; Dottino, Peter R. ; Martignetti, John A. ; Gabra, Hani ; Juhl, Hartmut ; Akeredolu, Teniola ; Stepa, Serghei ; Hoon, Dave ; Ahn, Keunsoo ; Kang, Koo Jeong ; Beuschlein, Felix ; Breggia, Anne ; Birrer, Michael ; Bell, Debra ; Borad, Mitesh ; Bryce, Alan H. ; Castle, Erik ; Chandan, Vishal ; Cheville, John ; Copland, John A. ; Farnell, Michael ; Flotte, Thomas ; Giama, Nasra ; Ho, Thai ; Kendrick, Michael ; Kocher, Jean-Pierre ; Kopp, Karla ; Moser, Catherine ; Nagorney, David ; O’Brien, Daniel ; O’Neill, Brian Patrick ; Patel, Tushar ; Petersen, Gloria ; Que, Florencia ; Rivera, Michael ; Roberts, Lewis ; Smallridge, Robert ; Smyrk, Thomas ; Stanton, Melissa ; Thompson, R. 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Mora ; Quintero-Aguilo, Mario ; Carlotti, Carlos Gilberto ; Dos Santos, Jose Sebastião ; Kemp, Rafael ; Sankarankuty, Ajith ; Tirapelli, Daniela ; Catto, James ; Agnew, Kathy ; Swisher, Elizabeth ; Creaney, Jenette ; Robinson, Bruce ; Shelley, Carl Simon ; Godwin, Eryn M. ; Kendall, Sara ; Shipman, Cassaundra ; Bradford, Carol ; Carey, Thomas ; Haddad, Andrea ; Moyer, Jeffey ; Peterson, Lisa ; Prince, Mark ; Rozek, Laura ; Wolf, Gregory ; Bowman, Rayleen ; Fong, Kwun M. ; Yang, Ian ; Korst, Robert ; Rathmell, W. Kimryn ; Fantacone-Campbell, J. Leigh ; Hooke, Jeffrey A. ; Kovatich, Albert J. ; Shriver, Craig D. ; DiPersio, John ; Drake, Bettina ; Govindan, Ramaswamy ; Heath, Sharon ; Ley, Timothy ; Van Tine, Brian ; Westervelt, Peter ; Rubin, Mark A. ; Lee, Jung Il ; Aredes, Natália D. ; Mariamidze, Armaz
Publié dans
Cell
Volume
173
Numéro
2
Pages
338-354.e15
Date
2018-04-05
Autres identifiant(s)
DOI: https://doi.org/10.1016/j.cell.2018.03.034
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Laboratoires
UPHUELSKEN
Le document apparaît dans
Production scientifique et compétences > SV - Faculté des sciences de la vie > ISREC - Institut suisse de recherche expérimentale sur le cancer > UPHUELSKEN - Unité du Prof. Huelsken
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Publié
Publications validées par des pairs
Travail produit à l'EPFL
Articles de journaux
Publié
Date de création de la notice
2018-06-04