000253449 001__ 253449
000253449 005__ 20190507134559.0
000253449 0247_ $$a10.1038/s41467-018-03386-7$$2doi
000253449 037__ $$aARTICLE
000253449 245__ $$aDesign and validation of a foldable and photovoltaic wide-field epiretinal prosthesis
000253449 260__ $$c2018-03-08
000253449 269__ $$a2018-03-08
000253449 336__ $$aJournal Articles
000253449 520__ $$aRetinal prostheses have been developed to fight blindness in people affected by outer retinal layer dystrophies. To date, few hundred patients have received a retinal implant. Inspired by intraocular lenses, we have designed a foldable and photovoltaic wide-field epiretinal prosthesis (named POLYRETINA) capable of stimulating wireless retinal ganglion cells. Here we show that within a visual angle of 46.3 degrees, POLYRETINA embeds 2215 stimulating pixels, of which 967 are in the central area of 5 mm, it is foldable to allow implantation through a small scleral incision, and it has a hemispherical shape to match the curvature of the eye. We demonstrate that it is not cytotoxic and respects optical and thermal safety standards; accelerated ageing shows a lifetime of at least 2 years. POLYRETINA represents significant progress towards the improvement of both visual acuity and visual field with the same device, a current challenging issue in the field.
000253449 542__ $$fCC BY
000253449 700__ $$g266003$$0249613$$aFerlauto, Laura
000253449 700__ $$aAiraghi Leccardi, Marta Jole Ildelfonsa
000253449 700__ $$aChenais, Naïg Aurelia Ludmilla
000253449 700__ $$aGilliéron, Samuel Charles Antoine
000253449 700__ $$aVagni, Paola
000253449 700__ $$aBevilacqua, Michele
000253449 700__ $$aWolfensberger, Thomas J.
000253449 700__ $$aSivula, Kevin
000253449 700__ $$aGhezzi, Diego
000253449 700__ $$aFerlauto, Laura
000253449 700__ $$aAiraghi Leccardi, Marta Jole Ildelfonsa
000253449 700__ $$aChenais, Naïg Aurelia Ludmilla
000253449 700__ $$aGilliéron, Samuel Charles Antoine
000253449 700__ $$aVagni, Paola
000253449 700__ $$aBevilacqua, Michele
000253449 700__ $$aWolfensberger, Thomas J.
000253449 700__ $$aSivula, Kevin
000253449 700__ $$aGhezzi, Diego
000253449 773__ $$k1$$j9$$tNature Communications$$q992
000253449 8560_ $$fdiego.ghezzi@epfl.ch
000253449 8564_ $$uhttps://infoscience.epfl.ch/record/253449/files/Ferlauto_et_al-2018-Nature_Communications.pdf$$zFinal$$s12099456
000253449 8564_ $$uhttps://infoscience.epfl.ch/record/253449/files/Ferlauto_et_al-2018-Nature_Communications.pdf?subformat=pdfa$$zFinal$$s7019698$$xpdfa
000253449 909C0 $$mdiego.ghezzi@epfl.ch$$xU13047$$yApproved$$pLNE$$0252540
000253449 909C0 $$yApproved$$pLIMNO$$xU12534$$mkevin.sivula@epfl.ch$$zBorel, Alain$$0252414
000253449 909CO $$qGLOBAL_SET$$pSB$$pSTI$$particle$$ooai:infoscience.epfl.ch:253449
000253449 960__ $$adiego.ghezzi@epfl.ch
000253449 961__ $$alaurence.gauvin@epfl.ch
000253449 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000253449 980__ $$aARTICLE
000253449 981__ $$aoverwrite