Although knowledge about the impact of light on individuals beyond vision is becoming substantial and less and less controversial, there is still a gap on how to properly address what type of lighting quality one should seek in an indoor space. What constitutes good lighting conditions from a truly holistic, human-centered perspective, i.e. encompassing both visual and non-visual aspects? Very few models are currently available to embed non-visual lighting in a design decision-making process beyond the ability to compare how effective different sources are expected to be in generating non-visual effects. The aim of this study is to make a first attempt to test whether the non-visual system may constitute a dominant driver for determining the quality of lighting conditions in a working context and how it seems to interact with visual factors.