EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens

We describe a lentivirus-encoded chimeric receptor, termed extracellular vesicle (EV)-internalizing receptor (EVIR), which enables the selective uptake of cancer-cell-derived EVs by dendritic cells (DCs). The EVIR enhances DC presentation of EV-associated tumor antigens to CD8+ T cells primarily through MHCI recycling and cross-dressing. EVIRs should facilitate exploring the mechanisms and implications of horizontal transfer of tumor antigens to antigen-presenting cells.


Published in:
Nature Methods, 15, 3, 183-186
Year:
Jan 22 2018
ISSN:
1548-7091
Keywords:
Laboratories:




 Record created 2017-12-14, last modified 2018-03-30


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