Ketene Aminal Phosphates: Competent Substrates for Enantioselective Pd(0)-Catalyzed C-H Functionalizations

Enantioselective Pd(0)-catalyzed C-H functionalizations of ketene aminal phosphates provide isoindoline scaffolds with high enantioselectivity at ambient temperature. The high level of enantiocontrol is enabled by a tailored monodentate electron-rich phosphine ligand featuring a point chiral phospholane module and a bulky atropchiral binaphthyl backbone.


Published in:
Acs Catalysis, 7, 11, 7417-7420
Year:
2017
Publisher:
Washington, American Chemical Society
ISSN:
2155-5435
Keywords:
Laboratories:




 Record created 2017-12-04, last modified 2018-03-17


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