000232605 001__ 232605
000232605 005__ 20190909115628.0
000232605 037__ $$aCONF
000232605 245__ $$aMedCo: Enabling Privacy-Conscious Exploration of Distributed Clinical and Genomic Data
000232605 269__ $$a2017
000232605 260__ $$c2017
000232605 336__ $$aConference Papers
000232605 520__ $$aBeing able to share large amounts of sensitive clinical and genomic data across several institutions is crucial for precision medicine to scale up. Unfor- tunately, existing solutions only partially address this challenge and are still unable to provide the strong privacy and security guarantees required by regulations (e.g., HIPAA, GDPR). As a result, currently only very limited datasets of non-sensitive and moderately useful information can be shared. In this paper, we introduce MedCo, the first operational system that enables an investigator to explore sensi- tive medical information distributed at several sites and protected with collective homomorphic encryption. MedCo builds on top of established and widespread technology from the biomedical informatics community, such as i2b2 and SHRINE, and relies on state-of-the-art secure protocols for processing encrypted distributed data and complying with regulations. As such, MedCo can be easily adopted by clinical sites thus paving the way to new unexplored data-sharing use cases. We tested MedCo in a real network of three institutions (EPFL, UNIL and CHUV) by focusing on an oncology use-case with real somatic mutations and clinical tumor data. The relatively low overhead introduced by MedCo shows that it represents a concrete and scalable solution for sharing privacy-conscious medical data.
000232605 6531_ $$ahomomorphic encryption
000232605 6531_ $$adata sharing
000232605 6531_ $$aprivacy
000232605 6531_ $$ai2b2
000232605 6531_ $$ashrine
000232605 6531_ $$aUn- Lynx
000232605 6531_ $$agenomic privacy
000232605 700__ $$0246661$$g222090$$aRaisaro, Jean Louis
000232605 700__ $$aTroncoso-Pastoriza, Juan Ramón
000232605 700__ $$aMisbach, Mickaël
000232605 700__ $$aGomes de Sá E Sousa, Joao André
000232605 700__ $$aPradervand, Sylvain
000232605 700__ $$aMissiaglia, Edoardo
000232605 700__ $$aMichielin, Olivier
000232605 700__ $$aFord, Bryan Alexander
000232605 700__ $$0240456$$g105427$$aHubaux, Jean-Pierre
000232605 7112_ $$dOctober 15, 2017$$cOrlando$$a4th International Workshop on ​Genome Privacy and Security (GenoPri'17)
000232605 8564_ $$zURL$$uhttp://www.genopri.org/uploads/3/9/9/9/39999711/genopri17_paper_6.pdf
000232605 8564_ $$zn/a$$yn/a$$uhttps://infoscience.epfl.ch/record/232605/files/GenoPri17_paper_6_CAMERA_READY.pdf$$s1447081
000232605 909C0 $$xU10426$$pLDS$$0252452
000232605 909CO $$qIC$$qGLOBAL_SET$$pconf$$ooai:infoscience.tind.io:232605
000232605 917Z8 $$x222090
000232605 937__ $$aEPFL-CONF-232605
000232605 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000232605 980__ $$aCONF