Room temperature C(sp(2))-H oxidative chlorination via photoredox catalysis

Photoredox catalysis has been developed to achieve oxidative C-H chlorination of aromatic compounds using NaCl as the chlorine source and Na2S2O8 as the oxidant. The reactions occur at room temperature and exhibit exclusive selectivity for C(sp(2))-H bonds over C(sp(3))-H bonds. The method has been used for the chlorination of a diverse set of substrates, including the expedited synthesis of key intermediates to bioactive compounds and a drug.


Published in:
Chemical Science, 8, 10, 7009-7013
Year:
2017
Publisher:
Cambridge, Royal Soc Chemistry
ISSN:
2041-6520
Laboratories:




 Record created 2017-11-08, last modified 2018-01-28

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