FORMINg a link between PTSD and AD

Epidemiological evidence suggests that people suffering from post-traumatic stress disorder have a higher risk for developing Alzheimer's disease. The underlying mechanisms, however, remained thus far unexplored. In this issue of The EMBO Journal, Agis-Balboa etal (2017) show that the actin-associated protein Formin 2 is reduced in both conditions and that its downregulation in mice accelerates Alzheimer-related pathophysiology via aberrant epigenetic and transcriptional changes. Treating mice with a histone deacetylase inhibitor (HDACi) delayed Alzheimer-related pathologies, lending experimental support to ongoing clinical trials with HDACis against traumatic memories and Alzheimer's disease.


Published in:
Embo Journal, 36, 19, 2809-2811
Year:
2017
Publisher:
Hoboken, Nature Publishing Group
ISSN:
0261-4189
Laboratories:




 Record created 2017-11-08, last modified 2018-03-17


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