000231988 001__ 231988
000231988 005__ 20190604054639.0
000231988 0247_ $$2doi$$a10.1002/anie.201709271
000231988 022__ $$a1433-7851
000231988 02470 $$2ISI$$a000418359400011
000231988 037__ $$aARTICLE
000231988 245__ $$aSoft Electrochemical Probes for Mapping the Distribution of Biomarkers and Injected Nanomaterials in Animal and Human Tissues
000231988 260__ $$bWiley-Blackwell$$c2017$$aWeinheim
000231988 269__ $$a2017
000231988 300__ $$a5
000231988 336__ $$aJournal Articles
000231988 520__ $$aMonitoring biomarkers and injected theranostic nanomaterials in tissues and organs plays a pivotal role in numerous medical applications ranging from cancer diagnostics to drug delivery. Scanning electrochemical microscopy has been demonstrated as a powerful tool to create highly resolved maps of the distributions of relevant biomolecules in cells and tissues without suffering from the optical interferences of conventional microscopy. We demonstrate for the first time the application of soft microelectrodes brushing in contact mode over large and thick tissues as well as organs that were immersed in an electrolyte solution. Amperometric currents were recorded based on the local flux of redox-active species locally and specifically generated by the biomarkers and nanomaterials to create maps of the biodistribution of graphene oxide nanoribbons in mouse livers, prognostic protein biomarkers in human melanoma and redox-active proteins in mouse heart.
000231988 6531_ $$aScanning Electrochemical Microscopy
000231988 6531_ $$aBioimaging
000231988 6531_ $$aElectrochemical bioimaging
000231988 6531_ $$aBiomarkers
000231988 6531_ $$aNanomaterials
000231988 6531_ $$aGraphene oxide nanoribbons
000231988 6531_ $$aTyrosinase
000231988 6531_ $$aMelanoma
000231988 6531_ $$aSkin Cancer
000231988 6531_ $$aSoft Probes
000231988 6531_ $$aSECM
000231988 700__ $$0247545$$g232930$$aLin, Tzu-En
000231988 700__ $$aLu, Yu-Jen
000231988 700__ $$aSun, Chia-Liang
000231988 700__ $$0241004$$g110882$$aPick, Horst
000231988 700__ $$aChen, Jyh-Ping
000231988 700__ $$0246751$$g208650$$aLesch, Andreas
000231988 700__ $$0242739$$g105258$$aGirault, Hubert
000231988 773__ $$j56$$tAngewandte Chemie International Edition$$k52$$q16498-16502
000231988 909C0 $$xU10100$$0252090$$pLEPA
000231988 909CO $$pSB$$particle$$ooai:infoscience.tind.io:231988
000231988 917Z8 $$x208650
000231988 917Z8 $$x208650
000231988 917Z8 $$x208650
000231988 937__ $$aEPFL-ARTICLE-231988
000231988 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000231988 980__ $$aARTICLE