Oxaliplatin reacts with DMSO only in the presence of water

Herein we show that oxaliplatin reacts rapidly with DMSO in aqueous solutions, despite being stable in pure DMSO and pure water. Furthermore, the reactivity of the clinically applied Pt(II) drugs in water/DMSO and PBS/DMSO mixtures, and the nature of the species formed were investigated by MS, NMR and RP-HPLC techniques.


Publié dans:
Dalton Transactions, 46, 28, 8929-8932
Année
2017
ISSN:
1477-9226
Laboratoires:




 Notice créée le 2017-10-09, modifiée le 2019-05-03

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