000231170 001__ 231170
000231170 005__ 20180913064513.0
000231170 0247_ $$2doi$$a10.3389/fmicb.2017.01928
000231170 022__ $$a1664-302X
000231170 02470 $$2ISI$$a000412297200001
000231170 037__ $$aARTICLE
000231170 245__ $$aCross-resistance of UV- or chlorine dioxide-resistant echovirus 11 to other disinfectants
000231170 260__ $$aLausanne$$bFrontiers Research Foundation$$c2017
000231170 269__ $$a2017
000231170 300__ $$a12
000231170 336__ $$aJournal Articles
000231170 520__ $$aThe emergence of waterborne viruses with resistance to disinfection has been demonstrated in the laboratory and in the environment. Yet, the implications of such resistance for virus control remain obscure. In this study we investigate if viruses with resistance to a given disinfection method exhibit cross-resistance to other disinfectants. Chlorine dioxide (ClO2)- or UV-resistant populations of echovirus 11 were exposed to five inactivating treatments (free chlorine, ClO2, UV radiation, sunlight and heat), and the extent of cross-resistance was determined. The ClO2-resistant population exhibited cross-resistance to free chlorine, but to none of the other inactivating treatments tested. We furthermore demonstrated that ClO2 and free chlorine act by a similar mechanism, in that they mainly inhibit the binding of echovirus 11 to its host cell. As such, viruses with host binding mechanisms that can withstand ClO2 treatment were also better able to withstand oxidation by free chlorine. Conversely, the UV-resistant population was not significantly cross-resistant to any other disinfection treatment. Overall, our results indicate that viruses with resistance to multiple disinfectants exist, but that they can be controlled by inactivating methods that operate by a distinctly different mechanism. We therefore suggest to utilize two disinfection barriers that act by different mechanisms in order to control disinfection-resistant viruses.
000231170 6531_ $$aenvironmental virology
000231170 6531_ $$avirus disinfection
000231170 6531_ $$aechovirus 11
000231170 6531_ $$across-resistance
000231170 6531_ $$awater treatment
000231170 700__ $$0246898$$aZhong, Qingxia$$g184799
000231170 700__ $$0247233$$aCarratala Ripolles, Anna$$g234442
000231170 700__ $$aOssola, Rachele
000231170 700__ $$0(EPFLAUTH)167843$$aBachmann, Virginie$$g167843
000231170 700__ $$0240649$$aKohn, Tamar$$g173999
000231170 773__ $$j8$$qArticle 1928$$tFrontiers in Microbiology
000231170 8564_ $$s1098131$$uhttps://infoscience.epfl.ch/record/231170/files/Zhong%20et%20al%202017.pdf$$yn/a$$zn/a
000231170 909C0 $$0252156$$pLCE$$xU11718
000231170 909CO $$ooai:infoscience.tind.io:231170$$particle$$pENAC
000231170 917Z8 $$x173999
000231170 917Z8 $$x173999
000231170 917Z8 $$x173999
000231170 917Z8 $$x173999
000231170 937__ $$aEPFL-ARTICLE-231170
000231170 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000231170 980__ $$aARTICLE