000230833 001__ 230833
000230833 005__ 20180913064454.0
000230833 0247_ $$2doi$$a10.1007/978-3-319-46669-9_5
000230833 020__ $$a978-3-319-46669-9
000230833 022__ $$a2195-3562
000230833 020__ $$a978-3-319-46668-2
000230833 02470 $$2ISI$$a000405220400005
000230833 037__ $$aCONF
000230833 245__ $$aA Computational Framework for the Design of Spinal Neuroprostheses
000230833 260__ $$aCham$$bSpringer International Publishing Ag$$c2017
000230833 269__ $$a2017
000230833 300__ $$a5
000230833 336__ $$aConference Papers
000230833 490__ $$aBiosystems and Biorobotics
000230833 520__ $$aSevere Spinal Cord Injury (SCI) alters the communication between supra-spinal centers and the sensorimotor networks coordinating limb movements, which are usually located below the injury. Epidural electrical stimulation of lumbar segments has shown the ability to enable descending motor control of the lower limbs in rodents and humans with severe paralysis. Using computational models and in vivo experiments in rodents, we found that EES facilitates motor control through the recruitment of muscle spindle feedback circuits. Stimulation protocols targeting these circuits allowed the selective modulation of synergistic muscle groups, both in rodents and non-human primates. This framework supports the design of stimulation strategies for humans.
000230833 700__ $$0246965$$aCapogrosso, Marco$$g229408$$uSwiss Fed Inst Technol EPFL, Ctr Neuroprosthet, Lausanne, Switzerland
000230833 700__ $$aBezard, Erwan$$uUniv Bordeaux, Bordeaux, France
000230833 700__ $$aBloch, Jocelyne
000230833 700__ $$0245952$$aCourtine, Gregoire$$g220184$$uSwiss Fed Inst Technol EPFL, Ctr Neuroprosthet, Lausanne, Switzerland
000230833 700__ $$0246201$$aMicera, Silvestro$$g218366$$uSwiss Fed Inst Technol EPFL, Ctr Neuroprosthet, Lausanne, Switzerland
000230833 7112_ $$a3rd International Conference on NeuroRehabilitation (ICNR)$$cSegovia, SPAIN$$dOCT 18-21, 2016
000230833 720_1 $$aIbanez, J$$eed.
000230833 720_1 $$aGonzalezvargas, J$$eed.
000230833 720_1 $$aAzorin, Jm$$eed.
000230833 720_1 $$aAkay, M$$eed.
000230833 720_1 $$aPons, Jl$$eed.
000230833 773__ $$j15$$q23-27$$tConverging Clinical And Engineering Research On Neurorehabilitation Ii, Vols 1 And 2
000230833 909C0 $$0252419$$pTNE$$xU12522
000230833 909C0 $$0252410$$pUPCOURTINE$$xU12556
000230833 909CO $$ooai:infoscience.tind.io:230833$$pSV$$pconf$$pSTI
000230833 917Z8 $$x278787
000230833 937__ $$aEPFL-CONF-230833
000230833 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000230833 980__ $$aCONF