000230058 001__ 230058
000230058 005__ 20181203024754.0
000230058 0247_ $$2doi$$a10.1109/TBCAS.2017.2733624
000230058 037__ $$aARTICLE
000230058 245__ $$aA Differential Electrochemical Readout ASIC with Heterogeneous Integration of Bio-nano Sensors for Amperometric Sensing
000230058 269__ $$a2017
000230058 260__ $$c2017
000230058 336__ $$aJournal Articles
000230058 520__ $$aA Monolithic biosensing platform is presented for miniaturized amperometric electrochemical sensing in CMOS. The system consists of a fully-integrated current readout circuit for differential current measurement as well as on-die sensors developed by growing Platinum nano-structures (Pt-nanoS) on top of electrodes implemented with the top metal layer. The circuit is based on the switch-capacitor technique and includes pseudo-differential integrators for concurrent sampling of the differential sensor currents. The circuit further includes a differential to single converter and a programmable gain amplifier prior to an ADC. The system is fabricated in 0.35 μm technology and measures current within ±20 μA with minimum input-referred noise of 0.47 pA and consumes 9.3 mW from a 3.3 V supply. Differential sensing for nano-structured sensors is proposed to build highly-sensitive and offset-free sensors for metabolite detection. This is successfully tested for bio-nano-sensors for the measurement of glucose in sub-mili Molar concentrations with the proposed readout IC. The on-die electrodes are nanos- tructured and cyclic voltammetry run successfully through the readout IC to demonstrate detection of H<sub>2</sub>O<sub>2</sub>.
000230058 6531_ $$aDifferential readout
000230058 6531_ $$aPotentiostat
000230058 6531_ $$aswitch-capacitor
000230058 6531_ $$aMetabolite sensing
000230058 6531_ $$aBio-nano-sensor
000230058 6531_ $$aon-die sensor
000230058 6531_ $$aPt- nanostructure
000230058 6531_ $$aGlucose sensor
000230058 700__ $$aGhoreishizadeh, Sara
000230058 700__ $$0245317$$g198935$$aTaurino, Irene
000230058 700__ $$0240269$$g167918$$aDe Micheli, Giovanni
000230058 700__ $$aCarrara, Sandro$$g182237$$0242413
000230058 700__ $$aGeorgiou, Pantelis
000230058 773__ $$j11$$tIEEE Transactions on Biomedical Circuits and Systems$$k5$$q1148-1159
000230058 909C0 $$xU11140$$0252283$$pLSI1
000230058 909CO $$ooai:infoscience.tind.io:230058$$pSTI$$pIC$$particle
000230058 917Z8 $$x112915
000230058 917Z8 $$x112915
000230058 917Z8 $$x112915
000230058 937__ $$aEPFL-ARTICLE-230058
000230058 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000230058 980__ $$aARTICLE