000229904 001__ 229904
000229904 005__ 20181203024752.0
000229904 0247_ $$2doi$$a10.3389/fnhum.2017.00336
000229904 022__ $$a1662-5161
000229904 02470 $$2ISI$$a000404483800001
000229904 037__ $$aARTICLE
000229904 245__ $$aBehavioral and cortical effects during attention driven brain-computer interface operations in spatial neglect: A feasibility case study
000229904 260__ $$bFrontiers Research Foundation$$c2017$$aLausanne
000229904 269__ $$a2017
000229904 300__ $$a8
000229904 336__ $$aJournal Articles
000229904 520__ $$aDuring the last years, several studies have suggested that Brain-Computer Interface (BCI) can play a critical role in the field of motor rehabilitation. In this case report, we aim to investigate the feasibility of a covert visuospatial attention (CVSA) driven BCI in three patients with left spatial neglect (SN). We hypothesize that such a BCI is able to detect attention task-specific brain patterns in SN patients and can induce significant changes in their abnormal cortical activity (alpha-power modulation, feature recruitment, and connectivity). The three patients were asked to control online a CVSA BCI by focusing their attention at different spatial locations, including their neglected (left) space. As primary outcome, results show a significant improvement of the reaction time in the neglected space between calibration and online modalities (p < 0.01) for the two out of three patients that had the slowest initial behavioral response. Such an evolution of reaction time negatively correlates (p < 0.05) with an increment of the Individual alpha-Power computed in the pre-cue interval. Furthermore, all patients exhibited a significant reduction of the inter-hemispheric imbalance (p < 0.05) over time in the parieto-occipital regions. Finally, analysis on the inter-hemispheric functional connectivity suggests an increment across modalities for regions in the affected (right) hemisphere and decrement for those in the healthy. Although preliminary, this feasibility study suggests a possible role of BCI in the therapeutic treatment of lateralized, attention-based visuospatial deficits.
000229904 6531_ $$abrain-computer interface
000229904 6531_ $$aspatial neglect
000229904 6531_ $$acovert visuospatial attention
000229904 6531_ $$aelectroencephalogram
000229904 6531_ $$aalpha oscillations
000229904 6531_ $$afunctional connectivity
000229904 700__ $$0242175$$g190240$$aTonin, Luca
000229904 700__ $$aPitteri, Marco
000229904 700__ $$0242179$$g192497$$aLeeb, Robert
000229904 700__ $$0245439$$g209107$$aZhang, Huaijian
000229904 700__ $$aMenegatti, Emanuele
000229904 700__ $$aPiccione, Francesco
000229904 700__ $$0240030$$g149175$$aMillán, José del R.
000229904 773__ $$j11$$tFrontiers in Human Neuroscience$$q336
000229904 909C0 $$xU12103$$0252018$$pCNBI
000229904 909C0 $$xU12599$$0252517$$pCNP
000229904 909CO $$pSTI$$particle$$ooai:infoscience.tind.io:229904
000229904 917Z8 $$x149175
000229904 937__ $$aEPFL-ARTICLE-229904
000229904 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000229904 980__ $$aARTICLE