000229756 001__ 229756
000229756 005__ 20181203024749.0
000229756 022__ $$a0953-816X
000229756 02470 $$2ISI$$a000402841700007
000229756 0247_ $$2doi$$a10.1111/ejn.13567
000229756 037__ $$aARTICLE
000229756 245__ $$aBilateral Rolandic operculum processing underlying heartbeat awareness reflects changes in bodily self-consciousness
000229756 269__ $$a2017
000229756 260__ $$bWiley-Blackwell$$c2017$$aHoboken
000229756 300__ $$a13
000229756 336__ $$aJournal Articles
000229756 520__ $$aExteroceptive bodily signals (including tactile, proprioceptive and visual signals) are important information contributing to self-consciousness. Moreover, prominent theories proposed that visceral signals about internal bodily states are equally or even more important for self-consciousness. Neuroimaging studies have described several brain regions which process signals related to bodily self-consciousness (BSC) based on the integration of exteroceptive signals (e. g. premotor cortex, angular gyrus, supramarginal gyrus and extrastriate body area), and that another brain region, the insula/operculum which is involved in interoception and interoceptive awareness, processes signals critical for self-awareness. Providing evidence for the integration of exteroceptive and interoceptive bodily signals, recent behavioral experiments have demonstrated that the manipulation of interoceptive (e. g. cardiac) signals, coupled with exteroceptive (e. g. visual) signals, also modulates BSC. Does this integration occur within or outside the structures described above? To this end, we adapted a recently designed protocol that uses cardio-visual stimulation to induce altered states of BSC to fMRI. Additionally, we measured neural activity in a classical interoceptive task. We found six brain regions (bilateral Rolandic operculum, bilateral supramarginal gyrus, right frontal inferior operculum and left temporal superior gyrus) that were activated differently during the interoception task as opposed to a control task. The brain regions which showed the highest selectivity for BSC based on our cardio-visual manipulation were found in the bilateral Rolandic operculum. Given our findings, we propose that the Rolandic operculum processes integrated exteroceptive-interoceptive signals that are necessary for interoceptive awareness as well as BSC.
000229756 6531_ $$aCardiac processing
000229756 6531_ $$ahigh-resolution fMRI
000229756 6531_ $$ainteroception
000229756 6531_ $$amultisensory integration
000229756 6531_ $$aCIBM-AIT
000229756 700__ $$uEcole Polytech Fed Lausanne, Ctr Neuroprosthet, Campus Biotech, Geneva, Switzerland$$aBlefari, Maria Laura
000229756 700__ $$uEcole Polytech Fed Lausanne, Ctr Neuroprosthet, Campus Biotech, Geneva, Switzerland$$aMartuzzi, Roberto
000229756 700__ $$uEcole Polytech Fed Lausanne, Ctr Neuroprosthet, Campus Biotech, Geneva, Switzerland$$aSalomon, Roy
000229756 700__ $$uEcole Polytech Fed Lausanne, Ctr Neuroprosthet, Campus Biotech, Geneva, Switzerland$$aBello-Ruiz, Javier
000229756 700__ $$0241247$$g146265$$uEcole Polytech Fed Lausanne, Ctr Neuroprosthet, Campus Biotech, Geneva, Switzerland$$aHerbelin, Bruno
000229756 700__ $$uEcole Polytech Fed Lausanne, Ctr Neuroprosthet, Campus Biotech, Geneva, Switzerland$$aSerino, Andrea
000229756 700__ $$uEcole Polytech Fed Lausanne, Ctr Neuroprosthet, Campus Biotech, Geneva, Switzerland$$aBlanke, Olaf$$g165806$$0240593
000229756 773__ $$j45$$tEuropean Journal Of Neuroscience$$k10$$q1300-1312
000229756 909C0 $$xU12599$$0252517$$pCNP
000229756 909C0 $$xU12623$$0252477$$pCIBM
000229756 909CO $$pSB$$particle$$ooai:infoscience.tind.io:229756
000229756 917Z8 $$x146265
000229756 937__ $$aEPFL-ARTICLE-229756
000229756 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000229756 980__ $$aARTICLE