Dicationic Ruthenium(II)-Arene-Curcumin Complexes Containing Methylated 1,3,5-Triaza-7-phosphaadamantane: Synthesis, Structure, and Cytotoxicity
Pettinari, Riccardo; Condello, Francesca; Marchetti, Fabio; Pettinari, Claudio; Smolenski, Piotr; Riedel, Tina; Scopelliti, Rosario; Dyson, Paul J.
2017

Abstract

Dicationic ruthenium(II)-p-cymene complexes containing curcumin ligands (curcH = curcumin, bdcurcH = bisdemethoxycurcumin) and ionic N-methyl-1,3,5-triaza-7-phosphaadamantane [PTA-Me]X (X = BF4 or I) have been synthesized and fully characterized for the first time. The solid-state structure of [Ru(p-cym)(curc)(PTA-Me)][SO3CF3][BF4] has also been determined by single-crystal X-ray diffraction. Modest antiproliferative activities of the complexes were observed against cis-platin-sensitive and cisplatin-resistant human ovarian carcinoma cells (A2780 and A2780cisR, respectively) and nontumorigenic human embryonic kidney (HEK293) cells.

Details

Title Dicationic Ruthenium(II)-Arene-Curcumin Complexes Containing Methylated 1,3,5-Triaza-7-phosphaadamantane: Synthesis, Structure, and Cytotoxicity
Author(s) Pettinari, Riccardo ; Condello, Francesca ; Marchetti, Fabio ; Pettinari, Claudio ; Smolenski, Piotr ; Riedel, Tina ; Scopelliti, Rosario ; Dyson, Paul J.
Published in European Journal Of Inorganic Chemistry
Pagination 6
Issue 22
Pages 2905-2910
Date 2017
Publisher Weinheim, Wiley-Blackwell
ISSN 1434-1948
Keywords
DOI https://doi.org/10.1002/ejic.201700183
Other identifier(s) View record in Web of Science
Laboratories LCOM
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCOM - Laboratory of Organometallic and Medicinal Chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2017-07-10

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