Microenvironmental regulation of tumour angiogenesis

Tumours display considerable variation in the patterning and properties of angiogenic blood vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming of neoplastic tissue is a multidimensional process regulated by cancer cells in concert with a variety of tumour-associated stromal cells and their bioactive products, which encompass cytokines and growth factors, the extracellular matrix and secreted microvesicles. In this Review, we discuss the extrinsic regulation of angiogenesis by the tumour microenvironment, highlighting potential vulnerabilities that could be targeted to improve the applicability and reach of anti-angiogenic cancer therapies.


Published in:
Nature Reviews Cancer, 17, 8, 457–474
Year:
2017
Publisher:
London, Nature Publishing Group
ISSN:
1474-175X
Keywords:
Laboratories:




 Record created 2017-06-20, last modified 2018-09-13

External link:
Download fulltext
URL
Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)