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000229027 037__ $$aPATENT
000229027 245__ $$aSolution for diagnosing or treating tissue pathology
000229027 260__ $$c2010
000229027 269__ $$a2010
000229027 336__ $$aPatents
000229027 520__ $$aPROBLEM TO BE SOLVED: To provide a composition for diagnosing and/or treating cancerous pathologies in the field of urology. ;SOLUTION: The invention relates to a 5-aminolevulinic acid ester (E-ALA) solution for producing a pharmaceutical preparation useful for diagnosing and/or treating tissue pathologies and/or cell pathologies by local radiation exposure using radiation emitted by a light source energy followed, in the case diagnosis, by detection of fluorescent protoporphyrin IX (PpIX). The E-ALA concentration (c) in the solution is less than 1% and ranges between 0.01 to 0.5%. The low E-ALA concentration in the solution increases the synthesis of PpIX and homogenizes its distribution in the cell layers while highly reducing the secondary toxicity for the treated cells. ;COPYRIGHT: (C)2010,JPO&INPIT
000229027 700__ $$aMarti, Alexandre
000229027 700__ $$aLange, Norbert
000229027 700__ $$aZellweger, Matthieu
000229027 700__ $$0241203$$aWagnieres, George$$g106697
000229027 700__ $$0240886$$aVan Den Bergh, Hubert$$g106613
000229027 700__ $$aJichlinski, Patrice
000229027 700__ $$aKucera, Pavel
000229027 909C0 $$0252085$$pTTO$$xU10021
000229027 909C0 $$0252376$$pLPAS
000229027 937__ $$aEPFL-PATENT-229027
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000229027 980__ $$aPATENT