Method for nmr spectrometry or mri measurement using dissolution dynamic nuclear polarization (dnp) with scavenging of free radicals
PROBLEM TO BE SOLVED: To provide a method for extending longitudinal relaxation time and transverse relaxation time in nuclear magnetic resonance (NMR), while removing free radicals from hyperpolarized solution. SOLUTION: A method for preparing samples for magnetic resonance measurement by using dissolution dynamic nuclear polarization-based hyperpolarization, includes the step (1.1) to prepare frozen beads of a first kind containing paramagnetic substances in addition to a solute under examination; the step (2.1) to insert the frozen beads into a polarization magnet; the step (3.1) to create a higher polarization state of the nuclei in a magnetic field; the step (4.1) to heat the sample up to room temperature, the step (5.1) to transfer samples into MR magnet; and the step (6.1) to perform MR measurement. Further, additional steps are included, the step (1.2) to prepare frozen beads of a second kind containing a reduction agent, and the step (2.2) to insert the frozen beads of a second kind together with the frozen beads of the first kind into the polarization magnet. ;COPYRIGHT: (C)2011,JPO&INPIT
42224247
Alternative title(s) : (de) Verfahren zur nmr-messung in lösung unter verwendung von dynamischer kernpolarisation (dnp) mit einfangen von freien radikalen (fr) Procédé de mesure par rmn utilisant la polarisation nucléaire dynamique de dissolution avec élimination des radicaux libres (en) Method for nmr measurements using dissolution dynamic nuclear polarization (dnp) with elimination of free radicals
TTO:6.0605
Patent number | Country code | Kind code | Date issued |
JP5667456 | JP | B2 | 2015-02-12 |
EP2348327 | EP | B1 | 2013-11-27 |
US8564288 | US | B2 | 2013-10-22 |
JP2011145297 | JP | A | 2011-07-28 |
EP2348327 | EP | A1 | 2011-07-27 |
US2011175611 | US | A1 | 2011-07-21 |