000228594 001__ 228594
000228594 005__ 20180913064346.0
000228594 022__ $$a08909369
000228594 037__ $$aARTICLE
000228594 245__ $$aSCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish
000228594 269__ $$a1998
000228594 260__ $$c1998
000228594 336__ $$aJournal Articles
000228594 520__ $$aSCL/Tal-1 is a transcription factor necessary for hematopoietic stem cell differentiation. Although SCL is also expressed in endothelial and neural progenitors, SCL function in these cells remains unknown. In the zebrafish mutant cloche (clo), SCL expression is nearly abolished in hematopoietic and vascular tissues. Correspondingly, it was shown previously that clo fails to differentiate blood and angioblasts. Genetic analysis demonstrates that the clo mutation is not linked to the SCL locus. Forced expression of SCL in clo embryos rescues the blood and vascular defects, suggesting that SCL acts downstream of clo to specify hematopoietic and vascular differentiation.
000228594 6531_ $$aAmino Acid Sequence
000228594 6531_ $$aanimal cell
000228594 6531_ $$aAnimalia
000228594 6531_ $$aAnimals
000228594 6531_ $$aArticle
000228594 6531_ $$aBasic Helix-Loop-Helix Transcription Factors
000228594 6531_ $$acell differentiation
000228594 6531_ $$aChromosome Mapping
000228594 6531_ $$aConserved Sequence
000228594 6531_ $$aDanio rerio
000228594 6531_ $$aDevelopmental
000228594 6531_ $$aDNA-Binding Proteins
000228594 6531_ $$aembryo
000228594 6531_ $$aendothelium
000228594 6531_ $$aGene expression
000228594 6531_ $$agene expression regulation
000228594 6531_ $$agenetic analysis
000228594 6531_ $$ahematopoietic stem cell
000228594 6531_ $$aHematopoietic Stem Cells
000228594 6531_ $$aMolecular Sequence Data
000228594 6531_ $$aMutation
000228594 6531_ $$anonhuman
000228594 6531_ $$aNonmammalian
000228594 6531_ $$apriority journal
000228594 6531_ $$aProto-Oncogene Proteins
000228594 6531_ $$atranscription factor
000228594 6531_ $$aTranscription Factors
000228594 6531_ $$aVascular
000228594 6531_ $$azebra fish
000228594 6531_ $$azebrafish
000228594 6531_ $$aZebrafish Proteins
000228594 700__ $$aLiao, E. C.
000228594 700__ $$aPaw, B. H.
000228594 700__ $$0250293$$aOates, A. C.$$g276451
000228594 700__ $$aPratt, S. J.
000228594 700__ $$aPostlethwait, J. H.
000228594 700__ $$aZon, L. I.
000228594 773__ $$j12$$k5$$q621-626$$tGenes and Development
000228594 8564_ $$uhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0032032466&partnerID=40&md5=d9e7379d611b41835f883b25322f0f4b$$zURL
000228594 909C0 $$0252604$$pUPOATES$$xU13325
000228594 909CO $$ooai:infoscience.tind.io:228594$$pSV$$particle
000228594 937__ $$aEPFL-ARTICLE-228594
000228594 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000228594 970__ $$aliao_scl/tal-1_1998/UPOATES
000228594 980__ $$aARTICLE