Breathe in and straighten your back: Hypoxia, notch, and scoliosis

In this issue of Cell, Sparrow et al. propose a new mechanism for sporadically occurring congenital scoliosis in which Notch signaling and hypoxia converge in the embryo on somite patterning via the segmentation clock. This interaction between hypoxia and a predisposed genetic background might underlie other birth defects with incomplete penetrance. © 2012 Elsevier Inc.


Published in:
Cell, 149, 2, 255-256
Year:
2012
ISSN:
00928674
Keywords:
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 Record created 2017-05-30, last modified 2018-09-13

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