000228374 001__ 228374
000228374 005__ 20180913064333.0
000228374 013__ $$aUS2015368209$$bUS$$cA1$$d20151224
000228374 013__ $$aEP2941428$$bEP$$cA1$$d20151111
000228374 013__ $$aWO2014106762$$bWO$$cA1$$d20140710
000228374 02470 $$2EPO Family ID$$a50073225
000228374 02470 $$2TTO$$a6.1364
000228374 037__ $$aPATENT
000228374 245__ $$a4-Pyrimidinylamino-benzenesulfonamide derivatives and their use for the inhibition of polo-like kinase 1 (PLK1) for the treatment of cancer and their use for the treatment of bacterial infections
000228374 260__ $$c2015
000228374 269__ $$a2015
000228374 336__ $$aPatents
000228374 520__ $$aThe present invention relates to 4-pyrimidinylamino-benzenesulfonamide derivatives of general formula (I) and pharmaceutically acceptable salts, solvates, hydrates, regioisomeric and polymorphic forms thereof, processes for manufacturing of them, the use of them, as well as pharmaceutical compositions containing at least one of them as pharmaceutically active agent(s) together with pharmaceutically acceptable carrier, excipient and/or diluents, especially for the inhibition of polo-like kinases (PLKs) and the treatment of cancer. Said 4-pyrimidinylamino-benzenesulfonamide compounds have been also identified as new drug candidates for the prevention and/or treatment of infectious diseases like bacterial diseases e.g. tuberculosis, including the currently multidrug-resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) as well as for preventing tuberculosis.
000228374 700__ $$aGreff, Zoltán
000228374 700__ $$aVarga, Zoltán
000228374 700__ $$aKéri, György
000228374 700__ $$aÕrfi, László
000228374 700__ $$aPató, János
000228374 700__ $$aBánhegyi, Péter
000228374 700__ $$aSzántai-kis, Csaba
000228374 700__ $$0243892$$aCole, Stewart$$g177247
000228374 700__ $$0244368$$aHartkoorn, Ruben$$g183097
000228374 700__ $$aSzékely, Rita Edina
000228374 909C0 $$0252085$$pTTO$$xU10021
000228374 909C0 $$0252302$$pUPCOL$$xU11742
000228374 909CO $$ooai:infoscience.tind.io:228374$$pSV
000228374 917Z8 $$x148230
000228374 937__ $$aEPFL-PATENT-228374
000228374 973__ $$aEPFL
000228374 980__ $$aPATENT