000228101 001__ 228101
000228101 005__ 20180913064325.0
000228101 013__ $$d20160609$$bUS$$cA1$$aUS2016158204
000228101 013__ $$d20150108$$bWO$$cA1$$aWO2015000800
000228101 013__ $$d20150107$$bEP$$cA1$$aEP2821072
000228101 02470 $$2EPO Family ID$$a48698959
000228101 02470 $$2TTO$$a6.1182
000228101 037__ $$aPATENT
000228101 245__ $$aPharmacological stimulation to facilitate and restore standing and walking functions in spinal cord motor disorders
000228101 260__ $$c2016
000228101 269__ $$a2016
000228101 336__ $$aPatents
000228101 520__ $$aThe invention relates to the selective targeting of specific α2 adrenergic receptor subtypes for facilitating and also restoring standing and walking in a subject affected by spinal cord disorders, in particular spinal cord injury. In particular, the improvement of locomotion by targeting specific receptor subtypes can be achieved by stimulation of the α2c receptor subtype using an α2c specific agonist or by blocking the α2a receptor subtype using α2a antagonists. A combination of an α2c agonist and an α2a antagonist is also provided for a synergistic effect. Alternatively, a large α2 agonist can be used in combination with an α2a antagonist to achieve specific stimulation of the α2c receptor. Pharmaceutical compositions, kit-of-parts and therapeutic systems comprising said agonists/antagonists as active agents are objects of the present invention. A robotic interface and epidural electric stimulation can also be used in combination with the compositions of the invention for restoring voluntary control of locomotion.
000228101 700__ $$0245952$$g220184$$aCourtine, Gregoire
000228101 700__ $$0246176$$g224044$$aBarraud, Quentin
000228101 700__ $$aMusienko, Pavel$$g226399$$0246287
000228101 909C0 $$0252085$$pTTO$$xU10021
000228101 909C0 $$xU12556$$0252410$$pUPCOURTINE
000228101 909CO $$pSV$$ooai:infoscience.tind.io:228101
000228101 917Z8 $$x278787
000228101 937__ $$aEPFL-PATENT-228101
000228101 973__ $$aEPFL
000228101 980__ $$aPATENT