Method for the generation of radicals for dynamic nuclear polarization and uses thereof for nmr, mrs and mri
A method for the preparation of a sample comprising highly polarized nuclear spins is proposed, comprising at least the following steps: a) provision of molecules with 1,2-dione structural units and/or molecules with 2,5-diene-1,4-dione structural units in the solid state; b) generation of radicals from these molecules by photo induced electron transfer by a first electromagnetic irradiation in the visible or ultraviolet frequency range in the solid state; c) dynamic nuclear polarization in the presence of a magnetic field in the solid state by applying a second electromagnetic irradiation with a frequency adapted to transfer spin polarization from the electrons to the nuclear spins leading to a highly polarized state thereof. Furthermore uses of correspondingly prepared samples for NMR, MRS and MRI experiments are proposed.
47884332
Alternative title(s) : (de) Verfahren zur erzeugung von radikalen für eine dynamische kernspinpolarisierung und anwendungen in der nmr, mrs und mrt (fr) Procédé de génération de radicaux pour polarisation nucléaire dynamique et leur utilisation en rmn, srm et irm
TTO:6.1267
Patent number | Country code | Kind code | Date issued |
US10114088 | US | B2 | 2018-10-30 |
EP2972441 | EP | B1 | 2016-11-30 |
US2016033590 | US | A1 | 2016-02-04 |
EP2972441 | EP | A1 | 2016-01-20 |
WO2014139573 | WO | A1 | 2014-09-18 |