Arene-Ruthenium(II) Complexes with Bioactive ortho-Hydroxydibenzoylmethane Ligands: Synthesis, Structure, and Cytotoxicity

The synthesis of a series of neutral arene-ruthenium (II) complexes (arene = p-cymene, hexamethylbenzene, and benzene) [(arene)Ru(HDB) Cl] derived from the reaction of the appropriate arene-ruthenium(II) dimers and ortho-hydroxydibenzoylmethane (HDBH), a potent inhibitor of cell proliferation, is described. In addition, related ionic complexes [(arene)Ru(HDB)(PTA)](SO3CF3) (PTA = 1,3,5-triaza-7-phosphaadamantane) have been prepared. The structure of three complexes has been confirmed by X-ray crystallography. The cytotoxicity of the complexes has been evaluated against human ovarian carcinoma cells (A2780 and A2780cisR), as well as against nontumorigenic human embryonic kidney (HEK293) cells, and compared to the free ligand and cisplatin. Two of the complexes, that is from the first series with p-cymene and hexamethylbenzene, display relevant activities against the cisplatin-resistant A2780cisR cancer cell line.


Published in:
European Journal Of Inorganic Chemistry, 12, 1800-1806
Year:
2017
Publisher:
Weinheim, Wiley-Blackwell
ISSN:
1434-1948
Keywords:
Laboratories:




 Record created 2017-05-01, last modified 2018-09-13


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