000227011 001__ 227011
000227011 005__ 20190225185111.0
000227011 0247_ $$2doi$$a10.1016/j.neuron.2016.12.001
000227011 022__ $$a0896-6273
000227011 02470 $$2ISI$$a000393117200022
000227011 037__ $$aARTICLE
000227011 245__ $$aMovement Initiation Signals in Mouse Whisker Motor Cortex
000227011 260__ $$bCell Press$$c2016$$aCambridge
000227011 269__ $$a2016
000227011 300__ $$a15
000227011 336__ $$aJournal Articles
000227011 520__ $$aFrontal cortex plays a central role in the control of voluntary movements, which are typically guided by sensory input. Here, we investigate the function of mouse whisker primary motor cortex (wM1), a frontal region defined by dense innervation from whisker primary somatosensory cortex (wS1). Optogenetic stimulation of wM1 evokes rhythmic whisker protraction (whisking), whereas optogenetic inactivation of wM1 suppresses initiation of whisking. Whole-cell membrane potential recordings and silicon probe recordings of action potentials reveal layer-specific neuronal activity in wM1 at movement initiation, and encoding of fast and slow parameters of movements during whisking. Interestingly, optogenetic inactivation of wS1 caused hyperpolarization and reduced firing in wM1, together with reduced whisking. Optogenetic stimulation of wS1 drove activity in wM1 with complex dynamics, as well as evoking long-latency, wM1-dependent whisking. Our results advance understanding of a well-defined frontal region and point to an important role for sensory input in controlling motor cortex.
000227011 700__ $$0244124$$g183369$$uEcole Polytech Fed Lausanne, Lab Sensory Proc, Brain Mind Inst, Fac Life Sci, CH-1015 Lausanne, Switzerland$$aSreenivasan, Varun
000227011 700__ $$0249089$$g255901$$uEcole Polytech Fed Lausanne, Lab Sensory Proc, Brain Mind Inst, Fac Life Sci, CH-1015 Lausanne, Switzerland$$aEsmaeili, Vahid
000227011 700__ $$0246584$$g229086$$uEcole Polytech Fed Lausanne, Lab Sensory Proc, Brain Mind Inst, Fac Life Sci, CH-1015 Lausanne, Switzerland$$aKiritani, Taro
000227011 700__ $$uEcole Polytech Fed Lausanne, Lab Sensory Proc, Brain Mind Inst, Fac Life Sci, CH-1015 Lausanne, Switzerland$$aGalan, Katia
000227011 700__ $$g165867$$uEcole Polytech Fed Lausanne, Lab Sensory Proc, Brain Mind Inst, Fac Life Sci, CH-1015 Lausanne, Switzerland$$aCrochet, Sylvain$$0240842
000227011 700__ $$aPetersen, Carl C. H.$$uEcole Polytech Fed Lausanne, Lab Sensory Proc, Brain Mind Inst, Fac Life Sci, CH-1015 Lausanne, Switzerland$$g157467$$0243169
000227011 773__ $$j92$$tNeuron$$k6$$q1368-1382
000227011 909C0 $$xU10837$$0252149$$pLSENS
000227011 909CO $$pSV$$particle$$ooai:infoscience.tind.io:227011
000227011 937__ $$aEPFL-ARTICLE-227011
000227011 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000227011 980__ $$aARTICLE