000227006 001__ 227006
000227006 005__ 20190317000653.0
000227006 0247_ $$2doi$$a10.1021/acs.bioconjchem.6b00577
000227006 022__ $$a1043-1802
000227006 02470 $$2ISI$$a000392459200019
000227006 037__ $$aARTICLE
000227006 245__ $$aSuperparamagnetic Nanoparticles as High Efficiency Magnetic Resonance Imaging T-2 Contrast Agent
000227006 260__ $$bAmerican Chemical Society$$c2017$$aWashington
000227006 269__ $$a2017
000227006 300__ $$a10
000227006 336__ $$aJournal Articles
000227006 520__ $$aNanoparticle-based magnetic resonance imaging T-2 negative agents are of great interest, and much effort is devoted to increasing cell loading capability while maintaining low cytotoxicity. Herein, two classes of mixed-ligand protected magnetic-responsive, bimetallic gold/iron nano particles (Au/Fe NPs) synthesized by a two-step method are presented. Their structure, surface composition, and magnetic properties are characterized. The two classes of sulfonated Au/Fe NPs, with an average diameter of 4 nm, have an average atomic ratio of Au to Fe equal to 7 or 8, which enables the Au/Fe NPs to be superparamagnetic with a blocking temperature of 56 K and 96 K. Furthermore, preliminary cellular studies reveal that both Au/Fe NPs show very limited toxicity. MRI phantom experiments show that r(2)/r(1) ratio of Au/Fe NPs is as high as 670, leading to a 66% reduction in T-2 relaxation time. These nanoparticles provide great versatility and potential for nanopartide-based diagnostics and therapeutic applications and as imaging contrast agents.
000227006 700__ $$uAMADEOLAB, Fdn IRCCS Ist Neurol Carlo Besta, Nanomed Lab, Via GA Amadeo 42, I-20133 Milan, Italy$$aSousa, Fernanda
000227006 700__ $$0243430$$g176429$$aSanavio, Barbara
000227006 700__ $$uAMADEOLAB, Fdn IRCCS Ist Neurol Carlo Besta, Nanomed Lab, Via GA Amadeo 42, I-20133 Milan, Italy$$aSaccani, Alessandra
000227006 700__ $$0244839$$g206081$$uEcole Polytech Fed Lausanne, Inst Mat, CH-1015 Lausanne, Switzerland$$aTang, Yun
000227006 700__ $$uFdn IRCCS Ist Neurol Carlo Besta, Lab Expt Imaging, Via Celoria 11, I-20133 Milan, Italy$$aZucca, Ileana
000227006 700__ $$uEcole Polytech Fed Lausanne, Inst Mat, CH-1015 Lausanne, Switzerland$$aCarney, Tamara M.
000227006 700__ $$uFdn IRCCS Ist Neurol Carlo Besta, Lab Expt Imaging, Via Celoria 11, I-20133 Milan, Italy$$aMastropietro, Alfonso
000227006 700__ $$uEcole Polytech Fed Lausanne, Inst Mat, CH-1015 Lausanne, Switzerland$$aSilva, Paulo H. Jacob
000227006 700__ $$uEcole Polytech Fed Lausanne, Inst Mat, CH-1015 Lausanne, Switzerland$$aCarney, Randy P.
000227006 700__ $$uEcole Polytech Fed Lausanne, Lab Xray Diffract, CH-1015 Lausanne, Switzerland$$aSchenk, Kurt
000227006 700__ $$0243437$$g186630$$aOmrani, Arash O.
000227006 700__ $$0247086$$g230087$$aHuang, Ping
000227006 700__ $$0247116$$g230109$$aYang, Lin
000227006 700__ $$g176429$$aRønnow, Henrik M.$$0243430
000227006 700__ $$aStellacci, Francesco$$uEcole Polytech Fed Lausanne, Inst Mat, CH-1015 Lausanne, Switzerland$$g196998$$0244724
000227006 700__ $$aKrol, Silke$$uAMADEOLAB, Fdn IRCCS Ist Neurol Carlo Besta, Nanomed Lab, Via GA Amadeo 42, I-20133 Milan, Italy
000227006 773__ $$j28$$tBioconjugate Chemistry$$k1$$q161-170
000227006 8564_ $$uhttps://infoscience.epfl.ch/record/227006/files/acs2Ebioconjchem2E6b00577.pdf$$zPublisher's version$$s4461096$$yPublisher's version
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000227006 937__ $$aEPFL-ARTICLE-227006
000227006 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000227006 980__ $$aARTICLE