000226865 001__ 226865
000226865 005__ 20180913064240.0
000226865 0247_ $$2doi$$a10.1038/nrc.2016.145
000226865 022__ $$a1474-175X
000226865 02470 $$2ISI$$a000395967200005
000226865 037__ $$aARTICLE
000226865 245__ $$aNotch as a tumour suppressor
000226865 260__ $$bNature Publishing Group$$c2017$$aLondon
000226865 269__ $$a2017
000226865 300__ $$a15
000226865 336__ $$aReviews
000226865 520__ $$aThe Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role in regulating development and homeostasis in various tissues. The cellular processes and events that it controls are diverse, and continued investigation over recent decades has revealed how the role of Notch signalling is multifaceted and highly context dependent. Consistent with the far-reaching impact that Notch has on development and homeostasis, aberrant activity of the pathway is also linked to the initiation and progression of several malignancies, and Notch can in fact be either oncogenic or tumour suppressive depending on the tissue and cellular context. The Notch pathway therefore represents an important target for therapeutic agents designed to treat many types of cancer. In this Review, we focus on the latest developments relating specifically to the tumour-suppressor activity of Notch signalling and discuss the potential mechanisms by which Notch can inhibit carcinogenesis in various tissues. Potential therapeutic strategies aimed at restoring or augmenting Notch-mediated tumour suppression will also be highlighted.
000226865 700__ $$uUniv Geneva, Dept Pathol & Immunol, CMU, Rue Michel Servet, CH-1211 Geneva 4, Switzerland$$aNowell, Craig S.
000226865 700__ $$g172749$$aRadtke, Freddy$$0240231
000226865 773__ $$j17$$tNature Reviews Cancer$$k3$$q145-159
000226865 909C0 $$xU11429$$0252086$$pUPRAD
000226865 909CO $$pSV$$preview$$ooai:infoscience.tind.io:226865
000226865 917Z8 $$x181933
000226865 937__ $$aEPFL-REVIEW-226865
000226865 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000226865 980__ $$aREVIEW