000226264 001__ 226264
000226264 005__ 20181203024608.0
000226264 0247_ $$2doi$$a10.1038/nmat4874
000226264 022__ $$a1476-1122
000226264 02470 $$2ISI$$a000402017000018
000226264 037__ $$aARTICLE
000226264 245__ $$aA fully organic retinal prosthesis restores vision in a rat model of degenerative blindness
000226264 260__ $$aLondon$$bNature Publishing Group$$c2017
000226264 269__ $$a2017
000226264 300__ $$a11
000226264 336__ $$aJournal Articles
000226264 520__ $$aThe degeneration of photoreceptors in the retina is one of the major causes of adult blindness in humans. Unfortunately, no effective clinical treatments exist for the majority of retinal degenerative disorders. Here we report on the fabrication and functional validation of a fully organic prosthesis for long-term in vivo subretinal implantation in the eye of Royal College of Surgeons rats, a widely recognized model of retinitis pigmentosa. Electrophysiological and behavioural analyses reveal a prosthesis-dependent recovery of light sensitivity and visual acuity that persists up to 6–10 months after surgery. The rescue of the visual function is accompanied by an increase in the basal metabolic activity of the primary visual cortex, as demonstrated by positron emission tomography imaging. Our results highlight the possibility of developing a new generation of fully organic, highly biocompatible and functionally autonomous photovoltaic prostheses for subretinal implants to treat degenerative blindness.
000226264 700__ $$aMaya-Vetencourt, José Fernando
000226264 700__ $$0249241$$aGhezzi, Diego$$g254787
000226264 700__ $$aAntognazza, Maria Rosa
000226264 700__ $$aColombo, Elisabetta
000226264 700__ $$aMete, Maurizio
000226264 700__ $$aFeyen, Paul
000226264 700__ $$aDesii, Andrea
000226264 700__ $$aBuschiazzo, Ambra
000226264 700__ $$aDi Paolo, Mattia
000226264 700__ $$aDi Marco, Stefano
000226264 700__ $$aTicconi, Flavia
000226264 700__ $$aEmionite, Laura
000226264 700__ $$aShmal, Dmytro
000226264 700__ $$aMarini, Cecilia
000226264 700__ $$aDonelli, Ilaria
000226264 700__ $$aFreddi, Giuliano
000226264 700__ $$aMaccarone, Rita
000226264 700__ $$aBisti, Silvia
000226264 700__ $$aSambuceti, Gianmario
000226264 700__ $$aPertile, Grazia
000226264 700__ $$aLanzani, Guglielmo
000226264 700__ $$aBenfenati, Fabio
000226264 773__ $$tNature Materials
000226264 909C0 $$0252540$$pLNE$$xU13047
000226264 909CO $$ooai:infoscience.tind.io:226264$$pSTI$$particle
000226264 917Z8 $$x254787
000226264 917Z8 $$x254787
000226264 937__ $$aEPFL-ARTICLE-226264
000226264 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000226264 980__ $$aARTICLE