000225803 001__ 225803
000225803 005__ 20181203024547.0
000225803 0247_ $$2doi$$a10.1007/s13738-016-0987-7
000225803 022__ $$a1735-207X
000225803 02470 $$2ISI$$a000392296300012
000225803 037__ $$aARTICLE
000225803 245__ $$aSynthesis, structural elucidation and biological activities of organotin(IV) derivatives of 4-(2-thienyl)butyric acid
000225803 260__ $$bSpringer$$c2017$$aNew York
000225803 269__ $$a2017
000225803 300__ $$a8
000225803 336__ $$aJournal Articles
000225803 520__ $$aA series of tri- and diorganotin(IV) derivatives of 4-(2-thienyl)butyric acid have been synthesized by the reaction of ligand acid with tri- and diorganotin salts in 1:1 and 2:1 molar ratios, respectively. The synthesized compounds have been confirmed by CHNS elemental analyses, FTIR, multinuclear NMR (H-1 and C-13) spectroscopy and X-ray diffraction studies. NMR data reveal a 5-coordinate geometry for the triorganotin(IV) derivatives, while 6-coordinate for the diorganotin(IV) derivatives, respectively. The X-ray crystallographic analysis of the compound 2 showed polymeric 5-coordinate trigonal bipyramidal geometry. Antimicrobial studies were also evaluated against different strains of bacteria (Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis and Staphylococcus aureus) and fungi (Mucor species, Aspergillus solani, Helminthosporium oryzae, Aspergillus flavus, Aspergillus niger) to establish the biological significance of these compounds. The synthesized compounds probably work by interfering with the ability of bacteria to form cell walls by keeping unwanted substances from entering their cells and stop the contents of their cells from leaking out due which the bacteria get die. The antifungal activity of some of the tested compound is comparable to that of the standard drug, terbinafine. From their antimicrobial results, it was concluded that they might be used as potential candidate for the generation of new antimicrobial drugs.
000225803 6531_ $$aOrganotin(IV) derivative
000225803 6531_ $$aNMR spectroscopy
000225803 6531_ $$aSingle-crystal X-ray
000225803 6531_ $$aAntimicrobial activity
000225803 700__ $$uAllama Iqbal Open Univ Islamabad, Islamabad, Pakistan$$aShaheen, Farzana
000225803 700__ $$uUniv Sci & Technol Bannu, Dept Chem, Bannu 28100, Pakistan$$aSirajuddin, Muhammad
000225803 700__ $$uQuaid I Azam Univ Islamabad, Dept Chem, Islamabad 45320, Pakistan$$aAli, Saqib
000225803 700__ $$uEcole Polytech Fed Lausanne, Inst Sci & Ingn Chim EPFL SB ISIC LCOM, BCH 2402 Batochime, CH-1015 Lausanne, Switzerland$$aDyson, Paul Joseph
000225803 700__ $$uQuaid I Azam Univ Islamabad, Dept Chem, Islamabad 45320, Pakistan$$aHaider, Ali
000225803 700__ $$uUniv Sargodha, Dept Phys, Sargodha, Pakistan$$aTahir, Muhammad Nawaz
000225803 700__ $$aShahid, Khadija
000225803 773__ $$j14$$tJournal Of The Iranian Chemical Society$$k2$$q387-394
000225803 909C0 $$xU10095$$0252439$$pISIC
000225803 909CO $$pSB$$particle$$ooai:infoscience.tind.io:225803
000225803 937__ $$aEPFL-ARTICLE-225803
000225803 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000225803 980__ $$aARTICLE