000225656 001__ 225656
000225656 005__ 20180317092517.0
000225656 0247_ $$2doi$$a10.1080/10255842.2017.1296954
000225656 022__ $$a1025-5842
000225656 02470 $$2ISI$$a000399353100005
000225656 037__ $$aARTICLE
000225656 245__ $$aMicromotion-induced peri-prosthetic fluid flow around a cementless femoral stem
000225656 260__ $$aAbingdon$$bTaylor & Francis$$c2017
000225656 269__ $$a2017
000225656 300__ $$a7
000225656 336__ $$aJournal Articles
000225656 520__ $$aMicromotion-induced interstitial fluid flow at the bone-implant interface has been proposed to play an important role in aseptic loosening of cementless implants. High fluid velocities are thought to promote aseptic loosening through activation of osteoclasts, shear stress induced control of mesenchymal stem cells differentiation, or transport of molecules. In this study, our objectives were to characterize and quantify micromotion-induced fluid flow around a cementless femoral stem using finite element modeling. With a 2D model of the bone-implant interface and full-factorial design, we first evaluated the relative influence of material properties, and bone-implant micromotion and gap on fluid velocity. Transverse sections around a femoral stem were built from computed tomography images, while boundary conditions were obtained from experimental measurements on the same femur. In a second step, a 3D model was built from the same dataset to estimate the shear stress experienced by cells hosted in the peri-implant tissues. The full-factorial design analysis showed that local micromotion had the most influence on peak fluid velocity at the interface. Remarkable variations in fluid velocity were observed in the macrostructures at the surface of the implant in the 2D transverse sections of the stem. The 3D model predicted peak fluid velocities extending up to 2.2 mm/s in the granulation tissue and to 3.9 mm/s in the trabecular bone. Peak shear stresses on the cells hosted in these tissues ranged from 0.1 Pa to 12.5 Pa. These results offer insight into mechanical stimuli encountered at the bone-implant interface.
000225656 6531_ $$acementless total hip arthroplasty
000225656 6531_ $$amicromotion
000225656 6531_ $$ainterstitial fluid flow
000225656 6531_ $$afemoral stem
000225656 700__ $$aMalfroy Camine, Valérie
000225656 700__ $$0240310$$aTerrier, Alexandre$$g106533
000225656 700__ $$0240508$$aPioletti, Dominique$$g103117
000225656 773__ $$j20$$k7$$q730-736$$tComputer Methods in Biomechanics and Biomedical Engineering
000225656 8564_ $$s372636$$uhttps://infoscience.epfl.ch/record/225656/files/CMBBE17%28Val%C3%A9rie%29.pdf$$yn/a$$zn/a
000225656 909CO $$ooai:infoscience.tind.io:225656$$particle$$pSTI
000225656 909C0 $$0252108$$pLBO$$xU10299
000225656 917Z8 $$x103117
000225656 917Z8 $$x103117
000225656 937__ $$aEPFL-ARTICLE-225656
000225656 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000225656 980__ $$aARTICLE