000225526 001__ 225526
000225526 005__ 20190317000632.0
000225526 037__ $$aPOST_TALK
000225526 245__ $$aThe OptoMEA platform: a new tool combining local chemical stimulation with distributed multi-electrode array recordings
000225526 269__ $$a2008
000225526 260__ $$c2008
000225526 336__ $$aPosters
000225526 520__ $$aWe present a novel OptoMEA platform that combines multisite electrical recording with local chemical stimulation. Applying UV light pulses through an array of optical fibres aligned to transparent indium-tin oxide electrodes of an MEA biochip leads to local compound uncaging (e.g. glutamate), thereby stimulating only the tissue/cells around the electrode vicinity. Experimental results obtained using the OptoMEA platform demonstrate its capability to uncage chemical compounds and to locally stimulate neuronal networks, thus providing a significant improvement in spatial control of chemical stimulation. It is expected that this methodology will be useful in facilitating studies of neuronal network systems, and may also find applications in drug screening.
000225526 700__ $$0(EPFLAUTH)101896$$g101896$$aHeuschkel, Marc Olivier
000225526 700__ $$0249241$$g254787$$aGhezzi, Diego
000225526 700__ $$aMenegon, Andrea
000225526 700__ $$aPedrocchi, Alessandra
000225526 700__ $$aMantero, Sara
000225526 700__ $$g102469$$aMakohliso, Solomzi$$0(EPFLAUTH)102469
000225526 700__ $$aValtorta, Flavia
000225526 700__ $$aFerrigno, Giancarlo
000225526 7112_ $$dJuly 8-11, 2008$$cReutlingen, Germany$$a6th International Meeting on Substrate-Integrated Micro Electrode Arrays (SIMEA)
000225526 8564_ $$uhttps://infoscience.epfl.ch/record/225526/files/Proceedings%20of%20SIMEA%202008.pdf$$zn/a$$s55220$$yn/a
000225526 909C0 $$xU13047$$0252540$$pLNE
000225526 909CO $$ooai:infoscience.tind.io:225526$$qGLOBAL_SET$$pSTI$$pposter
000225526 917Z8 $$x254787
000225526 917Z8 $$x254787
000225526 937__ $$aEPFL-POSTER-225526
000225526 973__ $$aOTHER
000225526 980__ $$aPOSTER