PhotoMEA: An opto-electronic biosensor for monitoring in vitro neuronal networks activity

PhotoMEA is a biosensor useful for the analysis of an in vitro neuronal network, fully based on optical methods. Its function is based on the stimulation of neurons with caged-glutamate and the recording of neuronal activity by fluorescence Voltage-Sensitive Dyes. The main advantage is that it will be possible to stimulate even at sub-single neuron level and to record with high resolution the activity of the entire network in the culture. A large-scale view of neuronal intercommunications offers a unique opportunity for testing the ability of drugs to affect neuronal properties as well as alterations in the behaviour of the entire network. The concept and a prototype for validation is described here in details.


Published in:
Proceedings of the Sixth International Workshop on Information Processing in Cells and Tissues, 108-118
Presented at:
Sixth International Workshop on Information Processing in Cells and Tissues (IPCAT), St William’s College, York, United Kingdom, August 30 - September 1, 2005
Year:
2005
Keywords:
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 Record created 2017-02-05, last modified 2018-03-17

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