Orientation invariant and non-parametric Axon Diameter Distribution mapping using PGSE and regularized discrete linear modeling

Axon Diameter Distributions (ADDs) change during brain development and are altered in several brain pathologies. Mapping ADDs non-invasively using dMRI could provide a useful biomarker, but existing methods are either parametric, orientation dependent, surmmarize the whole ADD as a single measure or use non-standard protocols. We propose to estimate the ADD from an orientation-invariant PGSE protocol optimized for axon diameter sensitivity, using a discrete linear model with smoothness and sparsity regularization. To our knowledge, we are the first to report orientationally invarant ADD estimates from dMRI data.


Published in:
Proceedings of the 24th annual meeting of the International Society for Magnetic Resonance in Medicine (ISMRM)
Presented at:
25th annual meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), Honolulu, HI, USA, April 22-27, 2017
Year:
2017
Keywords:
Laboratories:




 Record created 2017-01-06, last modified 2018-03-17


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