A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides
Awad, Loay; Jejelava, Nino; Burai, Ritwik; Lashuel, Hilal A
2016

Abstract

We present the design, synthesis, and characterization of a novel photocaged glutamine derivative (modified on the side chain of glutamine), and describe its use in enhancing peptide stability and solubility. Our results demonstrate that this approach can be used to develop molecular switches to control the folding and β-sheet formation of amyloidogenic peptides.

Details

Title A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides
Author(s) Awad, Loay ; Jejelava, Nino ; Burai, Ritwik ; Lashuel, Hilal A
Published in Chembiochem : a European journal of chemical biology
Pagination 8
Volume 17
Issue 24
Pages 2353-2360
Date 2016
Publisher Weinheim, Wiley-Blackwell
ISSN 1439-7633
Keywords
DOI https://doi.org/10.1002/cbic.201600474
Other identifier(s) View record in Web of Science
Laboratories LMNN
Record Appears in Scientific production and competences > SV - School of Life Sciences > BMI - Brain Mind Institute > LMNN - Laboratory of Molecular Neurobiology and Neuroproteomics
Work produced at EPFL
Journal Articles
Published
Record creation date 2017-01-04

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