000223961 001__ 223961
000223961 005__ 20180913064104.0
000223961 0247_ $$2doi$$a10.1002/mds.23418
000223961 022__ $$a1531-8257
000223961 037__ $$aARTICLE
000223961 245__ $$aInterhemispheric motor networks are abnormal in patients with Gilles de la Tourette syndrome
000223961 260__ $$bWiley-Blackwell$$c2010
000223961 269__ $$a2010
000223961 336__ $$aJournal Articles
000223961 520__ $$aBrain imaging has shown altered corpus callosum (CC) morphology in patients with Gilles de la Tourette syndrome (GTS). Yet it is unclear whether these morphological changes are associated with altered interhemispheric interactions. Here, we combined transcranial magnetic stimulation (TMS) with diffusion tensor magnetic resonance imaging (DTI) to explore functional and structural interhemispheric connections between the left and right motor hand areas. We studied 14 unmedicated GTS patients without psychiatric comorbidity (2 women, mean age 35.5 years) and 15 healthy volunteers (3 women, mean age 35 years). Left-to-right and right-to-left interhemispheric inhibitions (IHIs) were measured in hand muscles with TMS. In 13 GTS patients and all healthy controls, we measured fractional anisotropy (FA) with DTI to examine the relation between functional measures of interhemispheric connectivity as derived by TMS and structural properties of the CC region that carries fibers interconnecting both motor cortices. In GTS patients, left-to-right IHI was weaker than right-to-left IHI. Left-to-right IHI in GTS patients was also reduced compared with healthy controls. Voxel-based morphometric analysis revealed that FA in the motor region of the CC did not differ between groups. However, there was a significant interaction between groups and the relation between regional FA and left-to-right IHI in the motor region of the CC. A negative linear relation between FA and left-to-right IHI was present in control subjects but not in patients. Our combined TMS-DTI approach demonstrates abnormal functional interhemispheric connectivity in GTS accompanied by an altered structure-function relationship in the motor CC.
000223961 700__ $$aBäumer, Tobias
000223961 700__ $$aThomalla, Götz
000223961 700__ $$aKroeger, Johan
000223961 700__ $$aJonas, Melanie
000223961 700__ $$aGerloff, Christian
000223961 700__ $$0250291$$aHummel, Friedhelm Christoph$$g276450
000223961 700__ $$aMüller-Vahl, Kirsten
000223961 700__ $$aSchnitzler, Alfons
000223961 700__ $$aSiebner, Hartwig Roman
000223961 700__ $$aOrth, Michael
000223961 700__ $$aMünchau, Alexander
000223961 773__ $$j25$$k16$$q2828-37$$tMovement disorders : official journal of the Movement Disorder Society
000223961 909C0 $$0252595$$pUPHUMMEL$$xU13320
000223961 909CO $$ooai:infoscience.tind.io:223961$$pSV$$particle
000223961 917Z8 $$x182396
000223961 937__ $$aEPFL-ARTICLE-223961
000223961 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000223961 980__ $$aARTICLE