000223915 001__ 223915
000223915 005__ 20180317094947.0
000223915 0247_ $$2doi$$a10.3389/fnagi.2015.00193
000223915 037__ $$aARTICLE
000223915 245__ $$aAlpha oscillatory correlates of motor inhibition in the aged brain
000223915 269__ $$a2015
000223915 260__ $$c2015
000223915 336__ $$aJournal Articles
000223915 520__ $$aExerting inhibitory control is a cognitive ability mediated by functions known to decline with age. The goal of this study is to add to the mechanistic understanding of cortical inhibition during motor control in aged brains. Based on behavioral findings of impaired inhibitory control with age we hypothesized that elderly will show a reduced or a lack of EEG alpha-power increase during tasks that require motor inhibition. Since inhibitory control over movements has been shown to rely on prior motor memory formation, we investigated cortical inhibitory processes at two points in time-early after learning and after an overnight consolidation phase and hypothesized an overnight increase of inhibitory capacities. Young and elderly participants acquired a complex finger movement sequence and in each experimental session brain activity during execution and inhibition of the sequence was recorded with multi-channel EEG. We assessed cortical processes of sustained inhibition by means of task-induced changes of alpha oscillatory power. During inhibition of the learned movement, young participants showed a significant alpha power increase at the sensorimotor cortices whereas elderly did not. Interestingly, for both groups, the overnight consolidation phase improved up-regulation of alpha power during sustained inhibition. This points to deficits in the generation and enhancement of local inhibitory mechanisms at the sensorimotor cortices in aged brains. However, the alpha power increase in both groups implies neuroplastic changes that strengthen the network of alpha power generation over time in young as well as elderly brains.
000223915 700__ $$aBönstrup, Marlene
000223915 700__ $$aHagemann, Julian
000223915 700__ $$aGerloff, Christian
000223915 700__ $$aSauseng, Paul
000223915 700__ $$aHummel, Friedhelm C
000223915 773__ $$j7$$q193$$tFrontiers in aging neuroscience
000223915 8564_ $$s915895$$uhttps://infoscience.epfl.ch/record/223915/files/fnagi-07-00193.pdf$$yPublisher's version$$zPublisher's version
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000223915 937__ $$aEPFL-ARTICLE-223915
000223915 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000223915 980__ $$aARTICLE